Pignolo Antonia, Aprile Maria, Gagliardo Cesare, Giammanco Giovanni Maurizio, D'Amelio Marco, Aridon Paolo, La Tona Giuseppe, Salemi Giuseppe, Ragonese Paolo
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Via Gaetano la Loggia n.1, 90129 Palermo, Italy.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, 90129 Palermo, Italy.
Neurol Int. 2021 Dec 6;13(4):695-700. doi: 10.3390/neurolint13040066.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against possible reinfection. We hypothesize that SARS-CoV-2 infection, as previously reported for other viruses, could drive an active inflammatory response that can contribute either to the onset of MS or its relapse. The presented data further support the importance of vaccination in individuals with MS.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与多种神经系统疾病有关，包括头痛、面神经麻痹、脑炎、中风、脱髓鞘疾病。本报告将讨论在SARS-CoV-2感染后早期开始的多发性硬化症（MS）发病和复发病例。在这两个病例中，磁共振成像（MRI）显示双侧广泛的皮质下和脑室周围活动性病变。针对SARS-CoV-2刺突抗原的血清IgG证实了血清转化，其滴度被认为对可能的再次感染没有绝对的保护作用。我们假设，正如之前针对其他病毒所报道的那样，SARS-CoV-2感染可能引发一种活跃的炎症反应，这种反应可能导致MS的发病或复发。所呈现的数据进一步支持了MS患者接种疫苗的重要性。
