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印度尼西亚明古鲁市一家公立医院中接种疫苗前的新冠肺炎合并症患者与非合并症患者肺炎治疗结果评估

Evaluation of Treatment Outcome for Pneumonia among Pre-Vaccinated COVID-19 Patients with/without Comorbidity in a Public Hospital in Bengkulu, Indonesia.

作者信息

Ramatillah Diana Laila, Gan Siew Hua, Sulaiman Syed Azhar Syed, Puja Dama, Abubakar Usman, Jaber Ammar Ali Saleh, Lukas Stefanus, Jusnita Nina

机构信息

Faculty of Pharmacy, Universitas 17 Agustus 1945 Jakarta, Jakarta 14350, Indonesia.

School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.

出版信息

Vaccines (Basel). 2021 Nov 30;9(12):1411. doi: 10.3390/vaccines9121411.

Abstract

Pneumonia is one of the common complications of SARS-CoV-2 infection where most patients have moderate to severe symptoms that pose a higher risk for death. This study aims to evaluate the treatment outcome of COVID-19-associated Pneumonia among patients with/without comorbidity in a public hospital in Indonesia. This is a retrospective cohort study involving unvaccinated confirmed COVID-19 patients admitted to the hospital between March and December 2020. All confirmed COVID-19 patients with Pneumonia (n = 1522) treated at the hospital were included. The majority of patients (99%) had mild COVID-19 symptoms while the remaining had moderate symptoms. The median age was about 32 years old and the average treatment duration was 6.25 ± 1.83 days. Most patients (88.8%) received a combination of azithromycin and oseltamivir. There was a very significant relationship ( < 0.001) between comorbidities with treatment and duration of treatment of Pneumonia in COVID-19 patients. Although most patients had Pneumonia and comorbidities, they were successfully treated with azithromycin and oseltamivir combination following approximately five days of treatment.

摘要

肺炎是新型冠状病毒感染的常见并发症之一,大多数患者有中度至重度症状,死亡风险较高。本研究旨在评估印度尼西亚一家公立医院中合并症患者和无合并症患者的新型冠状病毒肺炎相关治疗结果。这是一项回顾性队列研究,纳入了2020年3月至12月期间在该医院住院的未接种疫苗的确诊新型冠状病毒感染患者。纳入了所有在该医院接受治疗的确诊新型冠状病毒肺炎患者(n = 1522)。大多数患者(99%)有轻度新型冠状病毒感染症状,其余患者有中度症状。中位年龄约为32岁,平均治疗时长为6.25 ± 1.83天。大多数患者(88.8%)接受了阿奇霉素和奥司他韦联合治疗。新型冠状病毒感染患者的合并症与肺炎治疗及治疗时长之间存在非常显著的关系(< 0.001)。尽管大多数患者患有肺炎且有合并症,但在接受约五天的治疗后,他们通过阿奇霉素和奥司他韦联合治疗成功治愈。

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本文引用的文献

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Comorbidity and its Impact on Patients with COVID-19.合并症及其对COVID-19患者的影响。
SN Compr Clin Med. 2020;2(8):1069-1076. doi: 10.1007/s42399-020-00363-4. Epub 2020 Jun 25.

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