Wang Shaotai, Song Dongsheng, Qiao Chunyan
Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, P.R.China.
Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Dec 25;38(6):1229-1234. doi: 10.7507/1001-5515.202104022.
With the continuous progress of materials science and biology, the significance of biomaterials with dual characteristics of materials science and biology is keeping on increasing. Nowadays, more and more biomaterials are being used in tissue engineering, pharmaceutical engineering and regenerative medicine. In repairing bone defects caused by trauma, tumor invasion, congenital malformation and other factors, a variety of biomaterials have emerged with different characteristics, such as surface charge, surface wettability, surface composition, immune regulation and so on, leading to significant differences in repair effects. This paper mainly discusses the influence of surface charge of biomaterials on bone formation and the methods of introducing surface charge, aiming to promote bone formation by changing the charge distribution on the surface of the biomaterials to serve the clinical treatment better.
随着材料科学和生物学的不断进步，兼具材料科学和生物学双重特性的生物材料的重要性日益增加。如今，越来越多的生物材料被应用于组织工程、制药工程和再生医学领域。在修复由创伤、肿瘤侵袭、先天性畸形等因素导致的骨缺损时，出现了多种具有不同特性的生物材料，如表面电荷、表面润湿性、表面组成、免疫调节等，这导致修复效果存在显著差异。本文主要探讨生物材料表面电荷对骨形成的影响以及引入表面电荷的方法，旨在通过改变生物材料表面的电荷分布来促进骨形成，从而更好地服务于临床治疗。
