Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Department of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu Province Hospital, Yangzhou University, Yangzhou, 225001, China.
Cell Commun Signal. 2022 Jan 3;20(1):1. doi: 10.1186/s12964-021-00806-y.
Pancreatic cancer is a highly malignant tumor and, is extremely difficult to diagnose and treat. Metastasis is one of the critical steps in the development of cancer and uses cell to cell communication to mediate changes in the microenvironment. Small extracellular vesicles (sEVs)-carry proteins, nucleic acids and other bioactive substances, and are important medium for communication between cells. There are two primary steps in sVEs-mediated metastasis: communication between pancreatic cancer cells and their surrounding microenvironment; and the communication between primary tumor cells and distant organ cells in distant organs that promotes angiogenesis, reshaping extracellular matrix, forming immunosuppressive environment and other ways to form appropriate pre-metastasis niche. Here, we explore the mechanism of localization and metastasis of pancreatic cancer and use sEVs as early biomarkers for the detection and treatment of pancreatic cancer. Video Abstract.
胰腺癌是一种高度恶性的肿瘤，极难诊断和治疗。转移是癌症发展的关键步骤之一，它利用细胞间通讯来调节微环境的变化。小细胞外囊泡（sEVs）携带蛋白质、核酸和其他生物活性物质，是细胞间通讯的重要媒介。sEVs 介导转移有两个主要步骤：胰腺癌细胞与其周围微环境之间的通讯；以及原发肿瘤细胞与远处器官中促进血管生成、重塑细胞外基质、形成免疫抑制环境等方式形成适当的转移前生态位的远处器官细胞之间的通讯。在这里，我们探讨了胰腺癌的定位和转移机制，并将 sEVs 用作胰腺癌检测和治疗的早期生物标志物。视频摘要。
