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哥伦比亚产 VIM-4 型金属β-内酰胺酶。

ST471 Producing VIM-4 Metallo-β-Lactamase in Colombia.

机构信息

Department of Microbiology, Bacteria and Cáncer Group, University of Antioquia, Medellín, Colombia.

Facultad de Ciencias de la Salud, Biociencias Group, Institución Universitaria Colegio Mayor de Antioquia, Medellín, Colombia.

出版信息

Microb Drug Resist. 2022 Mar;28(3):288-292. doi: 10.1089/mdr.2021.0031. Epub 2022 Jan 4.

DOI:10.1089/mdr.2021.0031
PMID:34990286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8968847/
Abstract

An isolate sequence-type 471 (ST471) producing Verona integron-encoded metallo-β-lactamases (VIM)-4 was recovered from a rectal swab in a patient without travel records with osteomyelitis in Colombia. The isolate carried a class 1 integron-borne gene with a 170-bp duplication in the 3' end of the gene, preceded by an ')-Ib gene. The genetic environment of , , and genes showed similarities to the backbone of pKKp4, an IncA/C-type plasmid from a strain carrying recovered in Kuwait. This is the first report of in in South America. Our results suggest that gene was found on an IncA/C-type plasmid that could play a role in the spread of VIM-4 carbapenemase in Colombia.

摘要

从哥伦比亚一名无旅行记录的骨髓炎患者的直肠拭子中分离出一株产 Verona 整合子编码的金属β-内酰胺酶（VIM）-4 的 471 型（ST471）分离株。该分离株携带一个整合子携带的 1 类基因，该基因在基因的 3'端有一个 170bp 的重复，前面有一个'-Ib 基因。和 基因的遗传环境与来自科威特的一株携带 基因的 菌株中的 IncA/C 型质粒 pKKp4 的骨架相似。这是南美洲首次报告发现 。我们的研究结果表明，基因位于 IncA/C 型质粒上，这可能在 VIM-4 碳青霉烯酶在哥伦比亚的传播中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/32a9a64ea05c/mdr.2021.0031_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/c6ddca64df51/mdr.2021.0031_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/2ce734c9a682/mdr.2021.0031_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/32a9a64ea05c/mdr.2021.0031_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/c6ddca64df51/mdr.2021.0031_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/2ce734c9a682/mdr.2021.0031_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab3b/8968847/32a9a64ea05c/mdr.2021.0031_figure3.jpg

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