Li Yu, Huang Yongsheng, Ren Shuwei, Xiao Xing, Cao Haotian, He Juan
Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China.
Cellular & Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Front Oncol. 2022 Jan 28;12:829389. doi: 10.3389/fonc.2022.829389. eCollection 2022.
Nuclear transport factor 2 (NUTF2) is a GDP-binding protein that participates in the nucleocytoplasmic transport process. The role of NUTF2 in cancer development is largely unknown and lacks systemic assessment across human cancers. In this study, we performed a pan-cancer analysis of NUTF2 in human cancers. Out of 33 types of cancers, 19 types had significantly different expression of NUTF2 between tumor and normal tissues. Meanwhile, survival analysis showed that NUTF2 could be an independent prognostic factor in several tumor types. Further analysis suggested that the expression of NUTF2 expression was correlated with the infiltration of immune cells, such as CD8 T cells, effector memory CD4 T cells, and cancer-associated fibroblasts in kidney renal clear cell carcinoma. Moreover, co-expression analysis showed the positive association between NUTF2 and cell proliferation biomarkers (MKI67and PCNA) and epithelial-mesenchymal transition markers (VIM, TWIST1, SNAI1, SNAI2, FN1, and CDH2), suggesting that NUTF2 plays important roles in regulating cancer proliferation and metastasis. This pan-cancer analysis of NUTF2 provides a systemic understanding of its oncogenic role across different types of cancers.
核转运因子2（NUTF2）是一种参与核质运输过程的GDP结合蛋白。NUTF2在癌症发展中的作用在很大程度上尚不清楚，并且缺乏对人类癌症的系统性评估。在本研究中，我们对人类癌症中的NUTF2进行了泛癌分析。在33种癌症类型中，有19种癌症的肿瘤组织和正常组织之间NUTF2表达存在显著差异。同时，生存分析表明NUTF2可能是几种肿瘤类型中的独立预后因素。进一步分析表明，在肾透明细胞癌中，NUTF2的表达与免疫细胞（如CD8 T细胞、效应记忆CD4 T细胞和癌症相关成纤维细胞）的浸润相关。此外，共表达分析显示NUTF2与细胞增殖生物标志物（MKI67和PCNA）以及上皮-间质转化标志物（VIM、TWIST1、SNAI1、SNAI2、FN1和CDH2）之间呈正相关，表明NUTF2在调节癌症增殖和转移中起重要作用。这种对NUTF2的泛癌分析为其在不同类型癌症中的致癌作用提供了系统性理解。
