Atallah Johnny, Mansour Michael K
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States.
Department of Medicine, Harvard Medical School, Boston, MA, United States.
Front Med (Lausanne). 2022 Feb 3;9:805107. doi: 10.3389/fmed.2022.805107. eCollection 2022.
Host-based diagnostics are a rapidly evolving field that may serve as an alternative to traditional pathogen-based diagnostics for infectious diseases. Understanding the exact mechanisms underlying a host-immune response and deriving specific host-response signatures, biomarkers and gene transcripts will potentially achieve improved diagnostics that will ultimately translate to better patient outcomes. Several studies have focused on novel techniques and assays focused on immunodiagnostics. In this review, we will highlight recent publications on the current use of host-based diagnostics alone or in combination with traditional microbiological assays and their potential future implications on the diagnosis and prognostic accuracy for the patient with infectious complications. Finally, we will address the cost-effectiveness implications from a healthcare and public health perspective.
基于宿主的诊断是一个快速发展的领域，可能成为传染病传统病原体诊断的替代方法。了解宿主免疫反应的具体机制并得出特定的宿主反应特征、生物标志物和基因转录本，有望实现更好的诊断，最终转化为更好的患者治疗结果。多项研究聚焦于免疫诊断的新技术和检测方法。在本综述中，我们将重点介绍近期关于单独使用基于宿主的诊断方法或与传统微生物检测方法联合使用的相关出版物，以及它们未来对感染性并发症患者诊断和预后准确性的潜在影响。最后，我们将从医疗保健和公共卫生角度探讨成本效益问题。
