Wang Yang, Xu Huiren, Dong Zaizai, Wang Zhiying, Yang Zhugen, Yu Xinge, Chang Lingqian
Key Laboratory for Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
School of Biomedical Information and Engineering, Hainan Medical University, Haikou, 471100, China.
Med Nov Technol Devices. 2022 Jun;14:100116. doi: 10.1016/j.medntd.2022.100116. Epub 2022 Feb 12.
Corona Virus Disease 2019 (COVID-19) has developed into a global pandemic in the last two years, causing significant impacts on our daily life in many countries. Rapid and accurate detection of COVID-19 is of great importance to both treatments and pandemic management. Till now, a variety of point-of-care testing (POCT) approaches devices, including nucleic acid-based test and immunological detection, have been developed and some of them has been rapidly ruled out for clinical diagnosis of COVID-19 due to the requirement of mass testing. In this review, we provide a summary and commentary on the methods and biomedical devices innovated or renovated for the quick and early diagnosis of COVID-19. In particular, some of micro and nano devices with miniaturized structures, showing outstanding analytical performances such as ultra-sensitivity, rapidness, accuracy and low cost, are discussed in this paper. We also provide our insights on the further implementation of biomedical devices using advanced micro and nano technologies to meet the demand of point-of-care diagnosis and home testing to facilitate pandemic management. In general, our paper provides a comprehensive overview of the latest advances on the POCT device for diagnosis of COVID-19, which may provide insightful knowledge for researcher to further develop novel diagnostic technologies for rapid and on-site detection of pathogens including SARS-CoV-2.
2019年冠状病毒病（COVID-19）在过去两年中已发展成为全球大流行，对许多国家的日常生活造成了重大影响。快速准确地检测COVID-19对治疗和疫情管理都非常重要。到目前为止，已经开发了多种即时检测（POCT）方法和设备，包括基于核酸的检测和免疫检测，由于大规模检测的要求，其中一些已被迅速排除用于COVID-19的临床诊断。在这篇综述中，我们对为快速早期诊断COVID-19而创新或改进的方法和生物医学设备进行了总结和评论。特别是，本文讨论了一些具有微型化结构的微纳设备，这些设备表现出超灵敏、快速、准确和低成本等出色的分析性能。我们还对使用先进的微纳技术进一步应用生物医学设备以满足即时诊断和家庭检测需求以促进疫情管理提出了见解。总体而言，我们的论文全面概述了用于诊断COVID-19的POCT设备的最新进展，这可能为研究人员进一步开发用于快速现场检测包括SARS-CoV-2在内的病原体的新型诊断技术提供有价值的知识。
