Xie Yue, Gao Pan, He Fangfang, Zhang Chun
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Gels. 2022 Feb 10;8(2):109. doi: 10.3390/gels8020109.
Hemorrhage, as a common trauma injury and clinical postoperative complication, may cause serious damage to the body, especially for patients with huge blood loss and coagulation dysfunction. Timely and effective hemostasis and avoidance of bleeding are of great significance for reducing body damage and improving the survival rate and quality of life of patients. Alginate is considered to be an excellent hemostatic polymer-based biomaterial due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, easy gelation and easy availability. In recent years, alginate hydrogels have been more and more widely used in the medical field, and a series of hemostatic related products have been developed such as medical dressings, hemostatic needles, transcatheter interventional embolization preparations, microneedles, injectable hydrogels, and hemostatic powders. The development and application prospects are extremely broad. This manuscript reviews the structure, properties and history of alginate, as well as the research progress of alginate hydrogels in clinical applications related to hemostasis. This review also discusses the current limitations and possible future development prospects of alginate hydrogels in hemostatic applications.
出血作为一种常见的创伤性损伤和临床术后并发症，可能会对身体造成严重损害，尤其是对于失血量大且有凝血功能障碍的患者。及时有效地止血和避免出血对于减少身体损伤、提高患者的生存率和生活质量具有重要意义。由于具有优异的生物相容性、生物可降解性、无毒、无免疫原性、易于凝胶化且易于获得，藻酸盐被认为是一种出色的基于聚合物的止血生物材料。近年来，藻酸盐水凝胶在医学领域的应用越来越广泛，并且已经开发出了一系列与止血相关的产品，如医用敷料、止血针、经导管介入栓塞制剂、微针、可注射水凝胶和止血粉等。其发展及应用前景极为广阔。本文综述了藻酸盐的结构、性质和历史，以及藻酸盐水凝胶在止血相关临床应用中的研究进展。本综述还讨论了藻酸盐水凝胶在止血应用中目前存在的局限性以及未来可能的发展前景。
