Firlar Ilayda, Altunbek Mine, McCarthy Colleen, Ramalingam Murugan, Camci-Unal Gulden
Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Gels. 2022 Feb 17;8(2):127. doi: 10.3390/gels8020127.
Chronic wounds severely affect 1-2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.
在发达国家，慢性伤口严重影响着1%至2%的人口。据报道，美国近650万人一生中至少患有一处慢性伤口。慢性伤口的治疗对于维持患者的身心健康以及提高其生活质量至关重要。治疗慢性伤口有许多方法，包括清创术、高压氧疗法、超声和电磁疗法、负压伤口疗法、皮肤移植和水凝胶敷料。其中，水凝胶敷料是一种有前景且可行的选择，因为其可调节的功能特性，如生物可降解性、粘附性以及抗菌、抗炎和促血管生成的生物活性，能够加速慢性伤口的愈合。本综述总结了慢性伤口的类型、愈合过程的阶段以及关键治疗方法。对基于水凝胶的敷料的多功能特性及其在治疗慢性伤口方面的优势进行了综述。还提供了市售水凝胶敷料的实例，以证明其在慢性伤口愈合方面优于其他类型伤口敷料的有效性。
