International Flavors & Fragrances-Lucas Meyer Cosmetics, Faran 4, Yavne 8122503, Israel.
International Flavors & Fragrances, 521 West 57th Street, New York, NY 10019, USA.
Mar Drugs. 2022 Jan 27;20(2):104. doi: 10.3390/md20020104.
Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. is a halophile microalga adapted to intense solar radiation through the production of carotenoids. We present a natural supercritical CO extract of rich in the colorless carotenoids phytoene and phytofluene. The extract exhibited antiglycation and anti-inflammatory activities in ex vivo testing, showing strongly reduced formation of N-ε-carboxy-methyl-lysine with exposure to methylglyoxal, reduced AGE receptor levels, and significantly reduced interleukins 6 and 8. In a placebo-controlled clinical study under intense solar exposure, the extract significantly reduced the skin's glycation scores and its sensitivity to histamine; key skin aging parameters were also significantly improved vs. placebo, including wrinkle counts and spots. These results demonstrate the value of this extract, rich in colorless carotenoids, as an antiglycative, anti-inflammatory, and antiaging active ingredient, including in high-irradiation contexts.
糖基化作用，以及由此产生的晚期糖基化终产物（AGEs）的积累，被认为是导致皮肤损伤和衰老的关键因素。 是一种嗜盐微藻，通过产生类胡萝卜素来适应强烈的太阳辐射。我们提供了一种富含无色类胡萝卜素番茄红素和叶黄素的 天然超临界 CO2 提取物。该提取物在离体测试中表现出抗糖化和抗炎活性，在接触甲基乙二醛时，明显减少 N-ε-羧甲基-赖氨酸的形成，降低 AGE 受体水平，并显著减少白细胞介素 6 和 8 的产生。在强烈阳光照射下进行的安慰剂对照临床试验中，该提取物显著降低了皮肤的糖化评分及其对组胺的敏感性；与安慰剂相比，关键的皮肤老化参数也得到了显著改善，包括皱纹计数和斑点。这些结果表明，这种富含无色类胡萝卜素的 提取物作为一种抗糖化、抗炎和抗衰老的活性成分具有很高的价值，包括在高辐射环境下。
