Sonmezer Meliha Cagla, Erul Enes, Sahin Taha Koray, Rudvan Al Ipek, Cosgun Yasemin, Korukluoglu Gulay, Zengin Humeyra, Telli Dizman Gülçin, Inkaya Ahmet Cagkan, Unal Serhat
Infectious Diseases and Clinical Microbiology Department, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey.
Internal Medicine Department, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey.
Vaccines (Basel). 2022 Feb 8;10(2):258. doi: 10.3390/vaccines10020258.
Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51-2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12-2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW's safety through challenging times.
医护人员作为一线工作者，被认为是感染新冠病毒风险最高的群体之一，尤其是直接参与患者护理的医护人员。然而，关于医护人员新冠病毒感染情况和血清阳性率的数据有限。因此，我们旨在通过土耳其一家三级护理医院的一项大型横断面研究，评估根据感染新冠病毒风险组别的医护人员血清阳性率。在疫苗接种计划之前，我们招募了1974名医护人员。在两项独立的半定量酶联免疫吸附测定中，检测了针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白亚基1（S1）的IgA或IgG抗体。研究对象中针对SARS-CoV-2的IgG、IgA或两者的阳性检测结果比例为19%（375/1974）。与患者有接触的一线医护人员（21.7%，相对风险2.1[1.51 - 2.92]）以及在新冠病房、重症监护病房或急诊科工作的医护人员（19.7%，相对风险1.61[1.12 - 2.32]），与没有日常患者接触的其他医护人员相比（[11.1%]），其抗SARS-CoV-2 IgG水平显著更高（<0.0001）。在中等风险组中护理普通患者的医护人员也持续面临着更高的接触SARS-CoV- 的风险。在艰难时期，我们应加强针对新冠病毒的预防措施，以保护医护人员的安全。
