Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
J Med Virol. 2022 Jul;94(7):3096-3100. doi: 10.1002/jmv.27685. Epub 2022 Mar 8.
Acute respiratory infections (ARIs) are one of the leading causes of illness and death among community members worldwide. Viral infections are the most common agents estimated to be involved in these patients. This study aimed to investigate the prevalence of human respiratory syncytial virus (hRSV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among children with ARIs. This study evaluated the presence of SARS-CoV-2 and hRSV in 168 throat and nasopharyngeal swab samples using real-time RT-PCR. All samples were collected from children under 5 years old with ARIs who attended Children's Medical Center, Tehran, Iran, and sent to the Iranian National Influenza Center with appropriate conditions in 2021. Chi-square and Fisher's exact tests were used for comparison of the data of the prevalence of hRSV and SARS-CoV-2 infections among children. Of 168 patients examined, 95 (57%) were male and 73 (43%) female. Out of them, 47 (28%) cases were younger than 1 year old and 121 cases (72%) were 1-5 years old. The most common clinical manifestations of patients were cough (78%), nausea (31%), diarrhea (27%), and fever (18%). Among 168 patients, no hRSV was detected, while the SARS-CoV-2 genome was identified in 16 (9.5%) patients. Among 16 positive cases of SARS-CoV-2, 8 (50%) were under 1 year old and 8 positive cases were 1-5 years old. This study was performed at cold months of the year but due to the coronavirus disease 2019 pandemic and adherence to health protocols, school closures, and virtual classes, no cases of hRSV infections were identified.
急性呼吸道感染（ARI）是全球社区成员患病和死亡的主要原因之一。病毒感染是最常见的致病因素。本研究旨在调查呼吸道合胞病毒（hRSV）和严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）在ARI 患儿中的流行情况。本研究使用实时 RT-PCR 评估了 168 例咽拭子和鼻咽拭子样本中 SARS-CoV-2 和 hRSV 的存在。所有样本均来自伊朗德黑兰儿童医疗中心因 ARI 就诊的 5 岁以下儿童，并在适当条件下于 2021 年送至伊朗国家流感中心。使用卡方检验和 Fisher 确切检验比较了 hRSV 和 SARS-CoV-2 感染在儿童中的流行率数据。在 168 例患者中，95 例（57%）为男性，73 例（43%）为女性。其中，47 例（28%）年龄小于 1 岁，121 例（72%）年龄为 1-5 岁。患者最常见的临床表现为咳嗽（78%）、恶心（31%）、腹泻（27%）和发热（18%）。在 168 例患者中，未检测到 hRSV，而 16 例（9.5%）患者的 SARS-CoV-2 基因组被鉴定。在 16 例 SARS-CoV-2 阳性病例中，8 例（50%）年龄小于 1 岁，8 例阳性病例年龄为 1-5 岁。本研究在一年中的寒冷月份进行，但由于 2019 年冠状病毒病大流行以及遵守卫生协议、学校关闭和在线课程，未发现 hRSV 感染病例。
