双功能 Spot 42 RNA 编码一个 15 个氨基酸的蛋白质，该蛋白调节 CRP 转录因子。
Dual-function Spot 42 RNA encodes a 15-amino acid protein that regulates the CRP transcription factor.
机构信息
Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Biological Sciences Graduate Program, University of Maryland, College Park, MD 20740.
出版信息
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2119866119. doi: 10.1073/pnas.2119866119. Epub 2022 Mar 3.
SignificanceDual-function RNAs base pair with target messenger RNAs as small regulatory RNAs and encode small protein regulators. However, only a limited number of these dual-function regulators have been identified. In this study, we show that a well-characterized base-pairing small RNA surprisingly also encodes a 15-amino acid protein. The very small protein binds the cyclic adenosine monophosphate receptor protein transcription factor to block activation of some promoters, raising the question of how many other transcription factors are modulated by unidentified small proteins.
意义
双功能 RNA 作为小调控 RNA 与靶信使 RNA 碱基配对，并编码小蛋白调控因子。然而，只有有限数量的这类双功能调控因子被鉴定出来。在本研究中，我们发现一个特征明确的碱基配对小 RNA 出人意料地也编码一个 15 个氨基酸的蛋白质。这个非常小的蛋白结合环磷酸腺苷受体蛋白转录因子以阻断某些启动子的激活，这就提出了一个问题，即有多少其他转录因子被未鉴定的小蛋白调节。
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