• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.编码大肠杆菌K12胆色素原脱氨酶的hemC基因座的核苷酸序列。
Nucleic Acids Res. 1986 Aug 11;14(15):6215-26. doi: 10.1093/nar/14.15.6215.
2
Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12.来自大肠杆菌K12重组菌株的胆色素原脱氨酶的纯化、结晶及性质
Biochem J. 1988 Sep 1;254(2):427-35. doi: 10.1042/bj2540427.
3
The sequence of hemC, hemD and two additional E. coli genes.hemC、hemD以及另外两个大肠杆菌基因的序列。
Nucleic Acids Res. 1988 Oct 25;16(20):9871. doi: 10.1093/nar/16.20.9871.
4
Availability of porphobilinogen controls appearance of porphobilinogen deaminase activity in Escherichia coli K-12.胆色素原的可获得性控制了大肠杆菌K-12中胆色素原脱氨酶活性的出现。
J Bacteriol. 1988 Oct;170(10):4969-71. doi: 10.1128/jb.170.10.4969-4971.1988.
5
Mutants of Escherichia coli K12 accumulating porphobilinogen: a new locus, hemC.积累胆色素原的大肠杆菌K12突变体：一个新基因座，hemC。
J Gen Microbiol. 1979 Mar;111(1):193-200. doi: 10.1099/00221287-111-1-193.
6
Nucleotide sequence of the guaB locus encoding IMP dehydrogenase of Escherichia coli K12.编码大肠杆菌K12 IMP脱氢酶的guaB基因座的核苷酸序列。
Nucleic Acids Res. 1985 Feb 25;13(4):1303-16. doi: 10.1093/nar/13.4.1303.
7
Molecular cloning and nucleotide sequence of the porphobilinogen deaminase gene, hemC, from Chlorobium vibrioforme.来自绿色颤蓝细菌的胆色素原脱氨酶基因hemC的分子克隆及核苷酸序列
Curr Microbiol. 1997 Apr;34(4):258-63. doi: 10.1007/s002849900179.
8
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.铜绿假单胞菌中hemC和hemD的同源物与编码黏液形成调节因子AlgR的基因相连。
Mol Gen Genet. 1994 Jan;242(2):177-84. doi: 10.1007/BF00391011.
9
Isolation of the Staphylococcus aureus hemCDBL gene cluster coding for early steps in heme biosynthesis.编码血红素生物合成早期步骤的金黄色葡萄球菌hemCDBL基因簇的分离。
Gene. 1997 Oct 15;199(1-2):231-9. doi: 10.1016/s0378-1119(97)00372-7.
10
Structure and expression of the Chlorobium vibrioforme hemA gene.绿弯菌属（Chlorobium vibrioforme）hemA基因的结构与表达
Arch Microbiol. 1991;156(4):281-9. doi: 10.1007/BF00262999.

引用本文的文献

1
encoding porphobilinogen deaminase plays an important role in chlorophyll biosynthesis and function in albino var. leaves.编码胆色素原脱氨酶在叶绿素生物合成中起重要作用，并在白化变种叶片中发挥功能。
PeerJ. 2021 Mar 30;9:e11118. doi: 10.7717/peerj.11118. eCollection 2021.
2
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.原核生物血红素生物合成：通往共同必需产物的多种途径。
Microbiol Mol Biol Rev. 2017 Jan 25;81(1). doi: 10.1128/MMBR.00048-16. Print 2017 Mar.
3
The common origins of the pigments of life-early steps of chlorophyll biosynthesis.生命色素的共同起源——叶绿素生物合成的早期步骤。
Photosynth Res. 1995 Jun;44(3):221-42. doi: 10.1007/BF00048596.
4
TolC-dependent exclusion of porphyrins in Escherichia coli.大肠杆菌中托品C（TolC）依赖的卟啉排出
J Bacteriol. 2008 Sep;190(18):6228-33. doi: 10.1128/JB.00595-08. Epub 2008 Jul 18.
5
Linkage map of Escherichia coli K-12, edition 10: the traditional map.大肠杆菌K-12连锁图谱，第10版：传统图谱。
Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984. doi: 10.1128/MMBR.62.3.814-984.1998.
6
Subcellular location of the tetrapyrrole synthesis enzyme porphobilinogen deaminase in higher plants: an immunological investigation.高等植物中四吡咯合成酶胆色素原脱氨酶的亚细胞定位：一项免疫学研究。
Planta. 1996;199(4):557-64. doi: 10.1007/BF00195187.
7
Discovery that the assembly of the dipyrromethane cofactor of porphobilinogen deaminase holoenzyme proceeds initially by the reaction of preuroporphyrinogen with the apoenzyme.发现胆色素原脱氨酶全酶的二吡咯甲烷辅因子的组装最初是通过尿卟啉原与脱辅基酶的反应进行的。
Biochem J. 1996 Jun 1;316 ( Pt 2)(Pt 2):373-6. doi: 10.1042/bj3160373.
8
The Escherichia coli visA gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway.大肠杆菌visA基因编码亚铁螯合酶，这是血红素生物合成途径中的最后一种酶。
J Bacteriol. 1993 Apr;175(7):2154-6. doi: 10.1128/jb.175.7.2154-2156.1993.
9
Detection of a high mutation frequency in exon 12 of the porphobilinogen deaminase gene in patients with acute intermittent porphyria.急性间歇性卟啉病患者中胆色素原脱氨酶基因第12外显子高突变频率的检测。
Hum Genet. 1993 Dec;92(6):619-22. doi: 10.1007/BF00420949.
10
Location of the hemE gene on the physical map of Escherichia coli.hemE基因在大肠杆菌物理图谱上的位置。
J Bacteriol. 1993 Dec;175(23):7749-50. doi: 10.1128/jb.175.23.7749-7750.1993.

本文引用的文献

1
Solid-phase Edman degradation. The use of p-phenyl diisothiocyanate to attach lysine- and arginine-containing peptides to insoluble resins.固相埃德曼降解法。使用对苯基二异硫氰酸酯将含赖氨酸和精氨酸的肽连接到不溶性树脂上。
FEBS Lett. 1972 Mar;21(1):67-70. doi: 10.1016/0014-5793(72)80165-0.
2
Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.人红细胞尿卟啉原I合酶的纯化及性质。稳定酶-底物中间体的鉴定。
J Biol Chem. 1980 Mar 10;255(5):1993-9.
3
Complete amino acid sequence of porcine heart citrate synthase.猪心柠檬酸合酶的完整氨基酸序列。
Biochemistry. 1982 Apr 27;21(9):2028-36. doi: 10.1021/bi00538a009.
4
Codon preference and its use in identifying protein coding regions in long DNA sequences.密码子偏好性及其在长DNA序列中识别蛋白质编码区的应用。
Nucleic Acids Res. 1982 Jan 11;10(1):141-56. doi: 10.1093/nar/10.1.141.
5
Mechanism of action of porphobilinogen deaminase. The participation of stable enzyme substrate covalent intermediates between porphobilinogen and the porphobilinogen deaminase from Rhodopseudomonas spheroides.胆色素原脱氨酶的作用机制。球形红假单胞菌中胆色素原与胆色素原脱氨酶之间稳定的酶底物共价中间体的参与情况。
Biochem J. 1981 Apr 1;195(1):177-81. doi: 10.1042/bj1950177.
6
Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics.从纤细裸藻中纯化胆色素原脱氨酶及其动力学研究。
Biochem J. 1981 Jan 1;193(1):301-10. doi: 10.1042/bj1930301.
7
Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes.原核基因中的密码子偏好使用：最佳密码子 - 反密码子相互作用能量与高效表达基因中的选择性密码子使用
Gene. 1982 Jun;18(3):199-209. doi: 10.1016/0378-1119(82)90157-3.
8
The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli.大肠杆菌腺苷酸环化酶基因的完整核苷酸序列。
Nucleic Acids Res. 1984 Dec 21;12(24):9427-40. doi: 10.1093/nar/12.24.9427.
9
Synthesis and use of synthetic oligonucleotides.合成寡核苷酸的合成与应用。
Annu Rev Biochem. 1984;53:323-56. doi: 10.1146/annurev.bi.53.070184.001543.
10
Linkage map of Escherichia coli K-12, edition 7.大肠杆菌K-12连锁图谱，第7版。
Microbiol Rev. 1983 Jun;47(2):180-230. doi: 10.1128/mr.47.2.180-230.1983.

编码大肠杆菌K12胆色素原脱氨酶的hemC基因座的核苷酸序列。

Nucleotide sequence of the hemC locus encoding porphobilinogen deaminase of Escherichia coli K12.

作者信息

Thomas S D, Jordan P M

出版信息

Nucleic Acids Res. 1986 Aug 11;14(15):6215-26. doi: 10.1093/nar/14.15.6215.

DOI:10.1093/nar/14.15.6215
PMID:3529035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC311632/
Abstract

Porphobilinogen deaminase, the product of the hemC locus in Escherichia coli K12, catalyses the tetrapolymerisation of porphobilinogen (PBG) into the hydroxymethylbilane, preuroporphyrinogen. The hemC locus has been subcloned from the Clarke and Carbon plasmid pLC41-4. The sequence of the hemC structural gene and flanking DNA was determined by the dideoxy chain termination method of Sanger. The structural gene for hemC is located within a 942bp sequence encoding the monomeric PBG deaminase, molecular weight 33,857. The extent of the coding region was confirmed by sequencing the N-terminus of the purified enzyme and by determination of the molecular weight. The hemC locus is closely linked to the cyaA locus, the genes being transcribed in a divergent manner. Upstream of the hemC coding region, a possible promoter and three repeated GGATG sequences were identified. This is the first report of a complete DNA sequence for a structural gene specifying an enzyme of the heme biosynthetic pathway in prokaryotes.

摘要

胆色素原脱氨酶是大肠杆菌K12中hemC基因座的产物，它催化胆色素原（PBG）四聚化形成羟甲基胆素，即尿卟啉原。hemC基因座已从克拉克和卡本质粒pLC41 - 4中进行亚克隆。hemC结构基因及侧翼DNA的序列通过桑格双脱氧链终止法测定。hemC的结构基因位于一段942bp的序列内，该序列编码单体PBG脱氨酶，分子量为33,857。通过对纯化酶的N端进行测序以及测定分子量，证实了编码区的范围。hemC基因座与cyaA基因座紧密相连，两个基因以相反方向转录。在hemC编码区上游，鉴定出一个可能的启动子和三个重复的GGATG序列。这是关于原核生物中指定血红素生物合成途径中一种酶的结构基因完整DNA序列的首次报道。