Baron M
Biol Psychiatry. 1986 Oct;21(12):1189-211. doi: 10.1016/0006-3223(86)90225-8.
The author reviews research strategies for identifying biological vulnerability traits and gene markers. The application of these methods to schizophrenia are discussed. He concludes that, based on the available evidence, none of the proposed biological traits qualifies as a major factor in the genetic susceptibility to schizophrenia. Some of these traits (such as attentional, neurophysiological, and brain morphology measures) appear promising, but the data are inadequate to arrive at a firm conclusion. Studies with gene markers have not produced consistent results. The author presents the methodological issues that concern this area of research and offers recommendations for future studies.
作者回顾了识别生物易感性特征和基因标记的研究策略。并讨论了这些方法在精神分裂症中的应用。他得出结论，基于现有证据，所提出的生物特征均不能被认定为精神分裂症遗传易感性的主要因素。其中一些特征（如注意力、神经生理学和脑形态测量）看起来很有前景，但数据不足以得出确凿结论。基因标记研究尚未产生一致的结果。作者提出了该研究领域涉及的方法学问题，并为未来研究提供了建议。
