Department of Medicine, University of Illinois at Chicago, 1747 W. Roosevelt Rd, Room 586 (MC 275), Chicago, IL, 60608, USA.
Curr Diab Rep. 2022 Apr;22(4):157-168. doi: 10.1007/s11892-022-01458-z. Epub 2022 Mar 18.
To synthesize evidence from randomized controlled trials on the effects of integrated behavioral interventions for comorbid obesity and depression in adults.
Seven trials (n = 33 to 409) were included. The quality of evidence was mixed. In 2 trials, integrated interventions led to greater improvements in both obesity and depression over 12 months, compared with usual care. Of 4 trials comparing integrated interventions with a standalone obesity intervention, 2 showed incremental effects on depression only, and 2 did not detect a significant effect for either outcome. One 3-arm trial compared an integrated intervention with standalone obesity and depression interventions and only detected incremental effects on obesity when compared with a standalone depression intervention. The effects of integrated interventions for comorbid obesity and depression are varied but promising. Implications for future research to guide intervention optimization and implement integrated interventions in clinical practice are provided.
综合随机对照试验的证据，评估针对肥胖合并抑郁的成年人的综合行为干预措施的效果。
纳入了 7 项试验（n=33 至 409）。证据质量参差不齐。在 2 项试验中，与常规护理相比，综合干预在 12 个月时在肥胖和抑郁两方面均有更大改善。在 4 项比较综合干预与单一肥胖干预的试验中，有 2 项仅显示对抑郁有增量效果，2 项对任何结果均未检测到显著效果。一项 3 臂试验比较了综合干预与单一肥胖和抑郁干预，仅发现与单一抑郁干预相比，对肥胖有增量效果。综合干预对肥胖合并抑郁的效果各不相同，但有一定前景。为了指导干预优化和在临床实践中实施综合干预，提出了未来研究的意义。
