接种 BNT162b2 后养老院中的 SARS-CoV-2 爆发：循环抗体定量的作用。
SARS-CoV-2 outbreak in a nursing home after vaccination with BNT162b2: A role for the quantification of circulating antibodies.
机构信息
Microbiology Department, Hospital Universitari Bellvitge, University of Barcelona-IDIBELL, L'Hospitalet de Llobregat, Spain; CIBER de Enfermedades Respiratorias (CIBERes), ISCIII, Madrid, Spain.
Microbiology Department, Hospital Universitari Bellvitge, University of Barcelona-IDIBELL, L'Hospitalet de Llobregat, Spain; CIBER de Enfermedades Respiratorias (CIBERes), ISCIII, Madrid, Spain.
出版信息
Vaccine. 2022 Apr 20;40(18):2531-2534. doi: 10.1016/j.vaccine.2022.03.026. Epub 2022 Mar 15.
We describe an outbreak of SARS-CoV-2 (B.1.351) in a nursing home. At the outbreak onset 96% of residents and 76% of HCW had received two doses of BNT162b2. Twenty-eight residents (28/53) and six HCW (6/33) were infected. Infected residents had lower levels of anti-S antibodies compared to those who were not infected (157 vs 552 U/mL). Among 50 residents with available serological status, nineteen (19/25) with serum concentration < 300 U/mL and seven (7/25) with concentration > 300 U/mL acquired SARS-CoV-2 (RR 2.7 [95 %CI 1.4-5.3]). The quantification of circulating antibodies could be useful in detecting people with an impaired immune response who are at high risk of acquiring and spreading SARS-CoV-2.
我们描述了一起发生在养老院的 SARS-CoV-2（B.1.351）爆发事件。在爆发开始时，96%的居民和 76%的 HCW 已接种了两剂 BNT162b2。28 名居民（28/53）和 6 名 HCW（6/33）被感染。感染居民的抗-S 抗体水平低于未感染者（157 与 552 U/mL）。在 50 名具有血清学状态的居民中，19 名（19/25）血清浓度<300 U/mL 和 7 名（7/25）浓度>300 U/mL 的居民感染了 SARS-CoV-2（RR 2.7 [95%CI 1.4-5.3]）。循环抗体的定量检测可能有助于发现免疫反应受损、感染和传播 SARS-CoV-2 风险较高的人群。
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