禁食模拟饮食对前列腺癌患者前瞻性队列代谢健康的影响：一项初步实施研究。

The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study.

机构信息

School of Medicine, National University of Ireland, Galway, Ireland.

Department of Radiation Oncology, Galway Clinic, Doughiske, Galway, Ireland.

出版信息

Prostate Cancer Prostatic Dis. 2023 Jun;26(2):317-322. doi: 10.1038/s41391-022-00528-3. Epub 2022 Mar 21.

DOI:10.1038/s41391-022-00528-3

PMID:35314788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10247368/

Abstract

BACKGROUND

This pilot prospective study investigated the effect of a periodic fasting mimicking diet (FMD) on metabolic health factors in patients with Prostate Cancer (PC). There is a well-documented association between PC and metabolic health. Impaired metabolic health is a significant risk factor for the development of PC, and a metabolic syndrome can be induced by hormonal therapies commonly required for its management. (ClinicalTrials.gov Identifier: NCT04292041).

METHODS

We introduced a periodic 4-day FMD -low in calories, sugars, and proteins but high in unsaturated fats -to a cohort of PC patients and features of metabolic syndrome. 29/35 patients completed 3-monthly cycles of the 4-consecutive day packaged FMD. We compared the subjects' baseline weight, abdominal circumference (AC), blood pressure (BP) and selected laboratory results to the same measurements 3-months after completing the FMD cycles.

RESULTS

Several important metabolic factors showed improvements post-intervention. On average patients' weights dropped by 3.79 kg (95% CI: -5.61, -1.97, p = 0.0002). AC was reduced on average by 4.57 cm, (95% CI: -2.27, -6.87, p = 0.0003). There was also a decrease in systolic and diastolic BP by 9.52 mmHg (95% CI: -16.16, -2.88, p = 0.0066) and 4.48 mmHg (95% CI: -8.85, -0.43, p = 0.0316) respectively. A sub-analysis indicates that FMD had more relevant effects in 'at-risk' patients than those with normal values of risk factors for metabolic syndrome. For example, subjects with baseline levels of systolic BP > 130 mmHg experienced a greater reduction in BP(-16.04 mmHg, p = 0.0001) than those with baseline systolic BP < 130 mmHg (-0.78 mmHg, p = 0.89).

CONCLUSIONS

The FMD cycles were safely introduced to this small cohort of PC patients with little or no observed toxicity, and a high overall compliance of 83%. Analysis of the metabolic variables showed an overall decrease in weight, AC, and BP. Larger clinical trials focused on metabolic risk factors, PC quality of life and progression free survival are needed to assess the effect of the FMD on prostate cancer patients.

摘要

背景

本前瞻性研究旨在探讨周期性断食模拟饮食（FMD）对前列腺癌（PC）患者代谢健康因素的影响。PC 与代谢健康之间存在明确的关联。代谢健康受损是 PC 发展的一个重要危险因素，代谢综合征可以通过其管理中常用的激素治疗来诱导。（临床试验.gov 标识符：NCT04292041）。

方法

我们向一组前列腺癌患者和代谢综合征特征的患者引入了周期性的 4 天 FMD-低热量、低糖和蛋白质，但高不饱和脂肪。29/35 名患者完成了 3 个月的 4 天连续 FMD 周期。我们将患者的基线体重、腰围（AC）、血压（BP）和选定的实验室结果与完成 FMD 周期后 3 个月的相同测量值进行了比较。

结果

干预后，一些重要的代谢因素有所改善。平均而言，患者体重下降了 3.79kg（95%CI：-5.61，-1.97，p=0.0002）。AC 平均减少了 4.57cm（95%CI：-2.27，-6.87，p=0.0003）。收缩压和舒张压也分别下降了 9.52mmHg（95%CI：-16.16，-2.88，p=0.0066）和 4.48mmHg（95%CI：-8.85，-0.43，p=0.0316）。一项亚分析表明，FMD 在代谢综合征危险因素处于“高危”的患者中比在正常值的患者中具有更相关的作用。例如，基线收缩压>130mmHg 的受试者的血压下降幅度更大（-16.04mmHg，p=0.0001），而基线收缩压<130mmHg 的受试者的血压下降幅度更小（-0.78mmHg，p=0.89）。