Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, United States.
Biochemistry. 2023 Dec 19;62(24):3488-3492. doi: 10.1021/acs.biochem.2c00051. Epub 2022 Mar 24.
CRISPR diagnostics have recently emerged as powerful diagnostic tools for the rapid detection of infections. The ultimate goal is to develop these diagnostics for the point of care, where patients quickly receive and easily interpret results. Although they are in their infancy, the COVID-19 pandemic has accelerated innovation of CRISPR diagnostics and led to an explosion of improvements to these systems. Challenges that have impeded the implementation at the point of care have been addressed, and CRISPR diagnostics have been dramatically simplified. Here we outline recent developments and advancements in CRISPR diagnostics that have pushed these technologies to the point of care.
CRISPR 诊断技术最近已成为快速检测感染的强大诊断工具。最终目标是开发用于即时护理的诊断技术，以便患者能快速获得并轻松解读检测结果。尽管它们还处于起步阶段，但 COVID-19 大流行加速了 CRISPR 诊断技术的创新，也促使这些系统得到了迅速的改进。为了克服在即时护理点实施的挑战，CRISPR 诊断技术得到了极大的简化。本文概述了将这些技术推向即时护理点的 CRISPR 诊断技术的最新进展和突破。
