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累及后脑的神经莱姆病:一例报告。

Neuroborreliosis with involvement of rhombencephalon: A case report.

作者信息

Svingen Hilde, Orrem Jon, Nørgaard Eskesen Arne

机构信息

Department of Internal Medicine, Akershus University Hospital, Mailbox 1000, 1478 Lørenskog, Norway.

Department of Radiology, Akershus University Hospital, Mailbox 1000, 1478 Lørenskog, Norway.

出版信息

IDCases. 2022 Mar 8;28:e01472. doi: 10.1016/j.idcr.2022.e01472. eCollection 2022.

Abstract

We describe a case of a 52 year-old woman who was hospitalized with rhombencephalitis caused by sensu lato. The patient presented with intermittent fever, dry cough, fatigue, global headache, night sweats, unintentional weight loss, and neurological symptoms like diplopia, tremor, paresthesia and ataxia. Examination of serum and cerebrospinal fluid (CSF) revealed positive -specific antibody index and presence of CSF oligoclonal IgG bands, indicating intrathecal synthesis of specific antibodies. The clinical and biochemical picture thus suggested neuroborreliosis. Unexpectedly a magnetic resonance imaging (MRI) scan demonstrated inflammation in rhombencephalon that are extremely rare in patients with neuroborreliosis. The patient was treated with intravenous ceftriaxone with rapid improvement of her symptoms. The MRI findings were in regress six weeks after onset of antibiotic treatment, and normalized after about seven months.

摘要

我们描述了一例52岁女性患者,她因伯氏疏螺旋体狭义种引起的菱脑炎而住院。患者出现间歇性发热、干咳、疲劳、全头痛、盗汗、体重意外减轻,以及复视、震颤、感觉异常和共济失调等神经症状。血清和脑脊液(CSF)检查显示特异性抗体指数阳性以及脑脊液寡克隆IgG带的存在,表明鞘内特异性抗体合成。临床和生化表现提示神经莱姆病。出乎意料的是,磁共振成像(MRI)扫描显示菱脑有炎症,这在神经莱姆病患者中极为罕见。患者接受了静脉注射头孢曲松治疗,症状迅速改善。抗生素治疗开始六周后,MRI结果逐渐消退,约七个月后恢复正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/8938859/e4da67fe622f/gr1.jpg

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