Fan Yiqi, Su Qing, Chen Junxiao, Wang Yong, He Shuai
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Front Oncol. 2022 Mar 8;12:836953. doi: 10.3389/fonc.2022.836953. eCollection 2022.
Glioma is the most common malignant tumor of the central nervous system (CNS), with high degree of malignancy and poor prognosis. The gut microbiome (GM) is composed of microorganisms with different properties and functions, which play an important role in human physiology and biological activities. It has been proved that GM can affect the development of glioma through natural immunity, but whether GM can affect glioma through adaptive immunity and whether there are some microorganisms in the GM that may affect glioma growth still remain unclear. In our study, we evaluated the relationship between GM and glioma. We proved that (I) glioma growth can induce structural changes of mouse GM, including the decreased abundance of and increased abundance of . (II) GM dysbiosis can downregulate Foxp3 expression in the brain and promote glioma growth. A balanced environment of GM can upregulate the expression of Foxp3 in the brain and delay the development of glioma. (III) The increased abundance of is associated with accelerated glioma progression, while its decreased abundance is associated with delayed glioma progression, which may be one of the key microorganisms affecting glioma growth. This study is helpful to reveal the relationship between GM and glioma development and provide new ideas for adjuvant therapy of glioma.
胶质瘤是中枢神经系统（CNS）最常见的恶性肿瘤，恶性程度高且预后差。肠道微生物群（GM）由具有不同特性和功能的微生物组成，在人体生理和生物活动中发挥着重要作用。已经证明GM可通过天然免疫影响胶质瘤的发展，但GM是否能通过适应性免疫影响胶质瘤以及GM中是否存在某些可能影响胶质瘤生长的微生物仍不清楚。在我们的研究中，我们评估了GM与胶质瘤之间的关系。我们证明：（I）胶质瘤生长可诱导小鼠GM的结构变化，包括[具体微生物1]丰度降低和[具体微生物2]丰度增加。（II）GM失调可下调脑中Foxp3的表达并促进胶质瘤生长。GM的平衡环境可上调脑中Foxp3的表达并延缓胶质瘤的发展。（III）[具体微生物2]丰度增加与胶质瘤进展加速相关，而其丰度降低与胶质瘤进展延迟相关，这可能是影响胶质瘤生长的关键微生物之一。本研究有助于揭示GM与胶质瘤发展之间的关系，并为胶质瘤的辅助治疗提供新思路。
