酿酒酵母中着丝粒（CEN3）对减数分裂交叉的抑制作用。
Repression of meiotic crossing over by a centromere (CEN3) in Saccharomyces cerevisiae.
作者信息
Lambie E J, Roeder G S
出版信息
Genetics. 1986 Nov;114(3):769-89. doi: 10.1093/genetics/114.3.769.
Abstract
The location of the centromere of chromosome III (CEN3) of Saccharomyces cerevisiae has been altered by means of transformation. The frequency of meiotic crossing over in the CEN3-PGK1 and LEU2-CEN3 intervals increases approximately 1.5- and fourfold, respectively, when CEN3 is repositioned at HIS4. The centromere-distal HIS4-LEU2 region experiences a three- to fivefold decrease in the frequency of meiotic exchange when CEN3 is repositioned at HIS4. The inhibition of meiotic crossing over is conferred by a 627-base-pair fragment of CEN3 DNA and is not dependent on the orientation of CEN3 relative to the rest of chromosome III.
摘要
通过转化手段改变了酿酒酵母第三条染色体（CEN3）着丝粒的位置。当CEN3重新定位到HIS4时，CEN3 - PGK1和LEU2 - CEN3区间的减数分裂交换频率分别增加约1.5倍和四倍。当CEN3重新定位到HIS4时，着丝粒远端的HIS4 - LEU2区域减数分裂交换频率下降三到五倍。减数分裂交换的抑制作用由CEN3 DNA的一个627个碱基对的片段赋予，且不依赖于CEN3相对于第三条染色体其余部分的方向。
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