Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Int J Mol Sci. 2022 Apr 5;23(7):4018. doi: 10.3390/ijms23074018.
The central nervous system (CNS) necessitates intricately coordinated immune responses to prevent neurological disease. However, the emergence of viruses capable of entering the CNS and infecting neurons threatens this delicate balance. Our CNS is protected from foreign invaders and excess solutes by a semipermeable barrier of endothelial cells called the blood-brain barrier. Thereby, viruses have implemented several strategies to bypass this protective layer and modulate immune responses within the CNS. In this review, we outline these immune regulatory mechanisms and provide perspectives on future questions in this rapidly expanding field.
中枢神经系统（CNS）需要精细协调的免疫反应来预防神经疾病。然而，能够进入中枢神经系统并感染神经元的病毒的出现威胁到这种微妙的平衡。我们的中枢神经系统被一层称为血脑屏障的内皮细胞半渗透屏障保护免受外来侵略者和过多溶质的侵害。因此，病毒已经实施了几种策略来绕过这个保护层并调节中枢神经系统内的免疫反应。在这篇综述中，我们概述了这些免疫调节机制，并就这个快速发展的领域的未来问题提供了观点。
