Liu Tianyu, Pang Qianyue, Mai Kang, He Xiaoting, Xu Li, Zhou Feiyan, Liu Yi
School of Pharmacy, Guangdong Pharmaceutical University Guangzhou 510006 China
School of Pharmaceutical and Chemical Engineering, Guangdong Pharmaceutical University Zhongshan 528458 China.
RSC Adv. 2022 Mar 28;12(16):9621-9627. doi: 10.1039/d2ra00561a. eCollection 2022 Mar 25.
A AgNPs@S,N-CQDs composite was synthesized by a one-step approach. It possessed AgNPs naturally surrounded by S,N-CQDs, and the size of the particles was found to be uniform and stable a series of characterization methods. The antibacterial properties of the composite material were studied, and it had good antibacterial properties against , , MRSA and . The minimum inhibitory concentrations were 63 μg mL against and MRSA and 32 μg mL against and . In addition, the AgNPs@S,N-CQDs composite had an antibacterial effect the generation of ROS, which was verified using the DCFH-DA kit. Finally, HepG2 cells were used to study its biocompatibility. The antibacterial properties and biocompatibility results show that the AgNPs@S,N-CQDs composite material can serve as a promising antibacterial agent.
通过一步法合成了AgNPs@S,N-CQDs复合材料。它具有被S,N-CQDs自然包围的AgNPs，通过一系列表征方法发现颗粒尺寸均匀且稳定。研究了该复合材料的抗菌性能，其对大肠杆菌、金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和枯草芽孢杆菌具有良好的抗菌性能。对大肠杆菌和耐甲氧西林金黄色葡萄球菌的最低抑菌浓度为63μg/mL，对金黄色葡萄球菌和枯草芽孢杆菌的最低抑菌浓度为32μg/mL。此外，AgNPs@S,N-CQDs复合材料通过活性氧的产生发挥抗菌作用，这使用DCFH-DA试剂盒得到了验证。最后，使用HepG2细胞研究其生物相容性。抗菌性能和生物相容性结果表明，AgNPs@S,N-CQDs复合材料可作为一种有前景的抗菌剂。
