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类黄酮:大自然的药物宝库。

Flavonoids: A Reservoir of Drugs from Nature.

机构信息

Department of Chemistry, Govt. Degree College, Beerwah-193411, JK, India.

Department of Higher Education, Govt. Degree College, JK, India.

出版信息

Mini Rev Med Chem. 2023;23(7):772-786. doi: 10.2174/1389557522666220420102545.

DOI:10.2174/1389557522666220420102545
PMID:35450522
Abstract

Flavonoids are associated with many plants and dietary foods; their chemical study has always attracted the interest of chemists working in the area of natural products and synthetic chemistry. Research in phytochemistry has produced many useful drugs. The analogs of flavonoids exhibit anticancer, anti-tuberculosis, anti-diabetic, antiviral, antibacterial, antioxidant, anti-inflammatory, antiproliferative, anti-spermatogenic, and antipsychotic activities. This review article highlights flavonoids' significance and medicinal application and displays a comparative overview of the biological activities of flavonoids and flavonoid derivatives. It covers almost all necessary reports for future directions in drug discovery.

摘要

类黄酮与许多植物和膳食食物有关;它们的化学研究一直吸引着从事天然产物和合成化学领域的化学家的兴趣。植物化学研究产生了许多有用的药物。类黄酮的类似物具有抗癌、抗结核、抗糖尿病、抗病毒、抗菌、抗氧化、抗炎、抗增殖、抗精子发生和抗精神病活性。本文重点介绍了类黄酮的重要性和药用应用,并对类黄酮及其衍生物的生物活性进行了比较概述。它涵盖了几乎所有未来药物发现方向的必要报告。

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1
Flavonoids: A Reservoir of Drugs from Nature.类黄酮:大自然的药物宝库。
Mini Rev Med Chem. 2023;23(7):772-786. doi: 10.2174/1389557522666220420102545.
2
[Advances in the structure-activity relationship study of natural flavonoids and its derivatives].[天然黄酮类化合物及其衍生物构效关系研究进展]
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Flavonoids: prospective drug candidates.黄酮类化合物:潜在的候选药物。
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A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid.黄酮类化合物的来源、毒性及生物活性的综合评述
Curr Top Med Chem. 2024;24(24):2093-2116. doi: 10.2174/0115680266316032240718050055.
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Important Flavonoids and Their Role as a Therapeutic Agent.重要类黄酮及其作为治疗剂的作用。
Molecules. 2020 Nov 11;25(22):5243. doi: 10.3390/molecules25225243.
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Chemistry and biological activities of flavonoids: an overview.黄酮类化合物的化学性质与生物活性:综述
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In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives.黄酮及其羟基化衍生物抗菌和抗氧化作用的计算机模拟研究与生物勘探
Molecules. 2017 May 24;22(6):869. doi: 10.3390/molecules22060869.
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Flavonoids: promising natural compounds against viral infections.黄酮类化合物:对抗病毒感染的有前景的天然化合物。
Arch Virol. 2017 Sep;162(9):2539-2551. doi: 10.1007/s00705-017-3417-y. Epub 2017 May 25.

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