Rea Hannah M, Øien Roald A, Shic Frederick, Webb Sara Jane, Ratto Allison B
Psychiatry & Behavioral Science Department, University of Washington, Seattle, WA, 98195, USA.
UiT-The Arctic University of Norway, PB 6060, 9037, Tromsø, Norway.
J Autism Dev Disord. 2023 Jul;53(7):2878-2890. doi: 10.1007/s10803-022-05566-3. Epub 2022 Apr 22.
The sex difference in the prevalence of autism spectrum disorder (ASD) may be magnified by sex differences on diagnostic measures. The current study compared autistic males and females on items on the gold-standard diagnostic measure, the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). In a sample of 8-to-17-year old autistic individuals from research (n = 229) and clinical settings (n = 238), females were less likely to show atypicalities on most items related to social-communication behaviors and on total and subscale scores. When controlling for overall intensity of symptomatology, no sex differences survived statistical corrections. Diagnostic criteria and/or gold-standard assessments may be less sensitive to female presentations of ASD and/or autistic females may exhibit fewer or less intense behaviors characteristic of ASD.
自闭症谱系障碍（ASD）患病率的性别差异可能会因诊断措施上的性别差异而被放大。本研究在金标准诊断工具《自闭症诊断观察量表第二版》（ADOS-2）的项目上对自闭症男性和女性进行了比较。在一个由来自研究机构（n = 229）和临床环境（n = 238）的8至17岁自闭症个体组成的样本中，女性在大多数与社交沟通行为相关的项目以及总分和子量表分数上表现出异常的可能性较小。在控制症状的总体严重程度后，没有性别差异在统计校正后仍然存在。诊断标准和/或金标准评估可能对女性ASD表现的敏感性较低，和/或自闭症女性可能表现出较少或不太强烈的ASD特征行为。
