Christ Bastian, Glaubitt Walther, Berberich Katrin, Weigel Tobias, Probst Jörn, Sextl Gerhard, Dembski Sofia
Fraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Neunerplatz 2, 97082 Würzburg, Germany.
Department Chemical Technology of Material Synthesis, University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Materials (Basel). 2022 Apr 8;15(8):2752. doi: 10.3390/ma15082752.
The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiO particles and coatings via the sol-gel process has frequently been published. However, synthesis protocols of sol-gel-derived TiO fibers are hardly known. In this publication, the authors present a synthesis and fabrication of purely sol-gel-derived TiO fiber fleeces starting from the liquid sol-gel precursor titanium ethylate (TEOT). Here, the -hydroxy-carboxylic acid lactic acid (LA) was used as a chelating ligand to reduce the reactivity towards hydrolysis of TEOT enabling a spinnable sol. The resulting fibers were processed into a non-woven fleece, characterized with FTIR, C-MAS-NMR, XRD, and screened with regard to their stability in physiological solution. They revealed an unexpected dependency between the LA content and the dissolution behavior. Finally, in vitro cell culture experiments proved their potential suitability as an open-mesh structured scaffold material, even for challenging applications such as therapeutic medicinal products (ATMPs).
新型纤维生物材料的开发以及医疗设备的进一步加工仍然具有挑战性。例如，二氧化钛（IV）是一种成熟的生物相容性材料，通过溶胶 - 凝胶法合成TiO颗粒和涂层的研究已屡见不鲜。然而，溶胶 - 凝胶法制备TiO纤维的合成方案却鲜为人知。在本出版物中，作者介绍了一种从液体溶胶 - 凝胶前体乙醇钛（TEOT）出发，纯溶胶 - 凝胶法制备TiO纤维毡的合成与制造方法。在此，使用羟基羧酸乳酸（LA）作为螯合配体，以降低TEOT对水解的反应活性，从而得到可纺丝溶胶。将所得纤维加工成无纺毡，用FTIR、C - MAS - NMR、XRD进行表征，并对其在生理溶液中的稳定性进行筛选。结果发现LA含量与溶解行为之间存在意想不到的相关性。最后，体外细胞培养实验证明了它们作为开放网状结构支架材料的潜在适用性，甚至适用于治疗性医药产品（ATMPs）等具有挑战性的应用。
