Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia.
Department of Pharmacology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya Str. 20, 127473 Moscow, Russia.
Int J Mol Sci. 2022 Apr 11;23(8):4234. doi: 10.3390/ijms23084234.
In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.
在这项研究中，我们开发了用油酸/油酸钠稳定的氧化铁纳米粒子，通过磁热疗可以对肿瘤发挥治疗作用。制备了氧化铁纳米粒子悬浮液并对其进行了表征。体内实验检测了合成物的毒性，结果表明其毒性可以忽略不计。组织学检查显示局部刺激性低，对内部器官形态无影响。评估了磁性热疗治疗移植的 Walker 256 癌的效果。将合成的粒子注入肿瘤，然后用交变磁场进行处理。在接受治疗的七只动物中，存活率为 85%，而在对照组（未治疗）中，所有动物均死亡。在体内实验中观察到合成液的物理化学和药物特性以及治疗效果，为使用注入的磁铁矿纳米粒子进行治疗热疗提供了思路。
