Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Center for Genomic and Computational Biology, Duke University, Durham, NC, 27708, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27708, USA.
Curr Opin Chem Biol. 2022 Jun;68:102147. doi: 10.1016/j.cbpa.2022.102147. Epub 2022 Apr 23.
Spatial patterning of cell populations is a ubiquitous phenomenon in nature. Patterns occur at various length and time scales and exhibit immense diversity. In addition to offering a deeper understanding of the emergence of patterns in nature, the ability to program synthetic patterns using living cells has the potential for broad applications. To date, however, progress in engineering pattern formation has been hampered by technical challenges. In this Review, we discuss recent advances in programming pattern formation in terms of biological insights, experimental and computational tool development, and potential applications.
细胞群体的空间模式是自然界中普遍存在的现象。模式出现在不同的长度和时间尺度上，并表现出巨大的多样性。除了提供对自然模式出现的更深层次的理解外，使用活细胞编程合成模式的能力具有广泛的应用潜力。然而，到目前为止，工程模式形成的进展受到技术挑战的阻碍。在这篇综述中，我们根据生物学见解、实验和计算工具的发展以及潜在应用讨论了编程模式形成的最新进展。
