McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Nat Commun. 2021 Mar 2;12(1):1390. doi: 10.1038/s41467-021-21740-0.
Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to 'outside-the-lab' scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.
合成生物学在满足全球需求方面具有巨大的潜力。然而，大多数当前的发展并不能立即转化为与受控实验室环境不同的“实验室外”场景。挑战包括实现长期储存稳定性，以及使用自主功能在资源有限和离网场景中运行。在这里，我们分析了为实验室外场景开发合成生物学平台的最新进展，重点关注三个主要的应用领域：生物生产、生物传感以及闭环治疗和益生菌输送。在这个视角中，我们强调了最新进展、进一步发展的领域、未来应用的可能性以及在其他学科界面创新的需求。
