Rogers S, James K S, Butland B K, Etherington M D, O'Brien J R, Jones J G
Atherosclerosis. 1987 Feb;63(2-3):137-43. doi: 10.1016/0021-9150(87)90113-4.
Sixty male volunteers were randomised to take 10-16 ml of a fish oil supplement (MaxEPA) or 10-16 ml of olive oil for a period of 3-6 weeks. A fall in serum triglyceride of 54% (P less than 0.01) and a fall in diastolic blood pressure of 7% (P less than 0.05) was attributable to taking fish oil supplements. The bleeding time was prolonged by 12%, but this did not reach conventional levels of statistical significance. A global test of heparin-neutralising activity, the heparin thrombin clotting time, increased by 14% (P = 0.05) but there was no demonstrable effect on thrombin time, fibrinogen or (intraplatelet) platelet factor 4. A fall in red cell pore transit time of 23% was attributable to fish oil, but was not statistically significant. There was no convincing evidence of an effect of fish oil supplementation on total serum cholesterol, HDL-cholesterol, blood counts or platelet aggregation. A beneficial effect of fish oil on the cardiovascular risk profile was confirmed in this study. However, with this regime changes in total cholesterol, HDL-cholesterol and platelet aggregation are of unlikely clinical importance.
60名男性志愿者被随机分为两组，一组服用10 - 16毫升鱼油补充剂（MaxEPA），另一组服用10 - 16毫升橄榄油，为期3 - 6周。服用鱼油补充剂可使血清甘油三酯下降54%（P < 0.01），舒张压下降7%（P < 0.05）。出血时间延长了12%，但未达到传统的统计学显著水平。肝素中和活性的一项整体检测指标——肝素凝血酶凝血时间增加了14%（P = 0.05），但对凝血酶时间、纤维蛋白原或（血小板内）血小板因子4没有明显影响。鱼油可使红细胞孔道通过时间下降23%，但无统计学显著性。没有令人信服的证据表明补充鱼油对总血清胆固醇、高密度脂蛋白胆固醇、血细胞计数或血小板聚集有影响。本研究证实了鱼油对心血管风险状况有有益作用。然而，按照这种方案，总胆固醇、高密度脂蛋白胆固醇和血小板聚集的变化在临床上不太可能具有重要意义。
