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使用微流控技术制造聚（乙二醇二丙烯酸酯）基中空微血管。

Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics.

作者信息

Aykar Saurabh S, Reynolds David E, McNamara Marilyn C, Hashemi Nicole N

机构信息

Department of Mechanical Engineering, Iowa State University Ames IA 50011 USA

Department of Biomedical Sciences, Iowa State University Ames IA 50011 USA.

出版信息

RSC Adv. 2020 Jan 24;10(7):4095-4102. doi: 10.1039/c9ra10264g. eCollection 2020 Jan 22.

DOI:10.1039/c9ra10264g
PMID:35492659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9049053/
Abstract

The microvasculature is a vital organ that distributes nutrients within tissues, and collects waste products from them, and which defines the environmental conditions in both normal and disease situations. Here, a microfluidic chip was developed for the fabrication of poly(ethylene glycol diacrylate) (PEGDA)-based hollow self-standing microvessels having inner dimensions ranging from 15 μm to 73 μm and displaying biocompatibility/cytocompatibility. Macromer solutions were hydrodynamically focused into a single microchannel to form a concentric flow regime, and were subsequently solidified through photopolymerization. This approach uniquely allowed the fabrication of hollow microvessels having a defined structure and integrity suitable for cell culturing.

摘要

微血管是一种重要器官，它在组织内分配营养物质，并从组织中收集代谢废物，在正常和疾病状态下都决定着环境条件。在此，开发了一种微流控芯片，用于制造基于聚（乙二醇二丙烯酸酯）（PEGDA）的中空自立微血管，其内部尺寸范围为15μm至73μm，并具有生物相容性/细胞相容性。大分子单体溶液通过流体动力学聚焦到单个微通道中以形成同心流态，随后通过光聚合固化。这种方法独特地允许制造具有适合细胞培养的确定结构和完整性的中空微血管。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/dba07ef7f4b9/c9ra10264g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/99ed8364b6cd/c9ra10264g-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/5ea39216423d/c9ra10264g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/dba07ef7f4b9/c9ra10264g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/99ed8364b6cd/c9ra10264g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/2125e11283ed/c9ra10264g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/8369e856f8c2/c9ra10264g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/5ea39216423d/c9ra10264g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dd/9049053/dba07ef7f4b9/c9ra10264g-f5.jpg

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