Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Nat Commun. 2022 May 2;13(1):2365. doi: 10.1038/s41467-022-29697-4.
The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal ( https://data.4dnucleome.org/ ), a repository for datasets generated in the 4DN network and relevant external datasets. Datasets were generated with a wide range of experiments, including chromosome conformation capture assays such as Hi-C and other innovative sequencing and microscopy-based assays probing chromosome architecture. All together, the 4DN data portal hosts more than 1800 experiment sets and 36000 files. Results of sequencing-based assays from different laboratories are uniformly processed and quality-controlled. The portal interface allows easy browsing, filtering, and bulk downloads, and the integrated HiGlass genome browser allows interactive visualization and comparison of multiple datasets. The 4DN data portal represents a primary resource for chromosome contact and other nuclear architecture data for the scientific community.
4D 核组学（4DN）网络旨在阐明细胞核中染色体的复杂结构和组织，以及它们在疾病生物学中的破坏所产生的影响。我们展示了 4DN 数据门户（https://data.4dnucleome.org/），这是一个用于存储 4DN 网络中生成的数据集以及相关外部数据集的存储库。数据集是通过广泛的实验生成的，包括染色体构象捕获测定，如 Hi-C 和其他创新性的测序和基于显微镜的测定，用于探测染色体结构。总的来说，4DN 数据门户拥有超过 1800 个实验集和 36000 个文件。来自不同实验室的基于测序的测定结果经过统一处理和质量控制。门户界面允许轻松浏览、筛选和批量下载，集成的 HiGlass 基因组浏览器允许对多个数据集进行交互式可视化和比较。4DN 数据门户是科学界研究染色体相互作用和其他核结构数据的主要资源。
