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COVID-19 患者冠状动脉钙化的系统评价和荟萃分析。

Systematic review and meta-analysis on coronary calcifications in COVID-19.

机构信息

ASST Santi Paolo E Carlo, Milano, Italy.

IRCCS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Emerg Radiol. 2022 Aug;29(4):631-643. doi: 10.1007/s10140-022-02048-y. Epub 2022 Apr 30.

DOI:10.1007/s10140-022-02048-y
PMID:35501615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059910/
Abstract

Chest CT is valuable to detect alternative diagnoses/complications of COVID-19, while its role for prognostication requires further investigation. Non-pulmonary radiological findings such as cardiovascular calcifications could increase the predictivity of clinical outcomes of COVID-19 patients beyond pulmonary involvement. Several observational studies have reported mixed results on the role of coronary calcifications in COVID-19 patients as a predictor of hospitalization, ventilatory support, and mortality. The purpose of the study is to systematically review the available evidence on the predictive role of cardiovascular calcifications in SARS-CoV2 disease. The meta-analysis confirms the prognostic significance of coronary calcifications on hospital mortality, and coronary calcifications (CAC ≠ 0) were associated with an OR for mortality of 2.19 (95% CI 1.36-3.52). CAC was neutral on respiratory outcomes, but it was associated with an increased trend of cardiovascular events. Coronary calcium appears as a promising biomarker imaging even in short-term outcomes (MACEs, hospital mortality) in a non-cardiovascular disease such as Sars-CoV2 infection. Further large studies are needed to confirm promising results of this imaging biomarker in non-cardiovascular disease.

摘要

胸部 CT 对于检测 COVID-19 的其他诊断/并发症具有重要价值，但其预后作用尚需进一步研究。非肺部的放射学表现，如心血管钙化，可能会增加 COVID-19 患者的临床结局的预测能力，超出肺部受累的范围。一些观察性研究报告了心血管钙化在 COVID-19 患者中作为住院、通气支持和死亡率预测因子的作用的混合结果。本研究的目的是系统地回顾关于心血管钙化在 SARS-CoV2 疾病中的预测作用的现有证据。荟萃分析证实了冠状动脉钙化对住院死亡率的预后意义，并且冠状动脉钙化（CAC ≠ 0）与死亡率的比值比（OR）为 2.19（95%置信区间 1.36-3.52）相关。CAC 在呼吸结局方面呈中性，但与心血管事件的增加趋势相关。即使在非心血管疾病（如 SARS-CoV2 感染）的短期结局（MACEs，住院死亡率）中，冠状动脉钙也似乎是一种有前途的生物标志物成像。需要进一步的大型研究来证实这种非心血管疾病中影像学生物标志物的有前途的结果。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c035/9059910/756a5a86187d/10140_2022_2048_Fig7_HTML.jpg
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The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification.性别与 COVID-19 死亡率之间隐藏的相互作用：心血管钙化的作用。
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