免疫复合物对抗原反应性B淋巴细胞的直接阻断。抗原与Fc受体的连接为产生IgM的细胞前体提供的“关闭”信号。
Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.
作者信息
Oberbarnscheidt J, Kölsch E
出版信息
Immunology. 1978 Jul;35(1):151-7.
Abstract
Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures, it can be demonstrated that neither T cells nor their products are required for this inhibition of IgM PFC formation. The blockade is at the level of B cells and cannot be overcome by LPS or TRF. The data demonstrate that cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is a blocking signal for B cells.
摘要
抗原-抗体复合物能有效抑制抗体形成的诱导。利用米谢尔-达顿培养法可以证明，这种对IgM形成细胞（PFC）形成的抑制并不需要T细胞及其产物。这种阻断作用发生在B细胞水平，且不能被脂多糖（LPS）或促胸腺细胞生成素（TRF）克服。数据表明，抗原-抗体复合物使抗原受体和Fc受体交联，这是一种针对B细胞的阻断信号。
相似文献
1
2
3
4
5
6
A role for T cell CD4 in contact mediated T dependent B cell activation.T细胞CD4在接触介导的T细胞依赖性B细胞活化中的作用。
Cell Immunol. 1996 Nov 1;173(2):236-45. doi: 10.1006/cimm.1996.0273.
7
8
9
10
Population changes in antigen-binding and antibody-secreting cells in the course of the immune response.免疫应答过程中抗原结合细胞和抗体分泌细胞的群体变化。
Soc Gen Physiol Ser. 1974;29:49-58.
引用本文的文献
1
Immunoregulatory characteristics of the in vitro anti-ssDNA response.体外抗单链DNA反应的免疫调节特性
Immunol Res. 1993;12(4):349-57. doi: 10.1007/BF02935508.
2
3
TG cells in peripheral blood lymphocytes from patients with rheumatoid arthritis.类风湿关节炎患者外周血淋巴细胞中的TG细胞。
Clin Exp Immunol. 1981 Sep;45(3):538-43.
4
5
Characteristics and function of Fc receptors on human lymphocytes.人淋巴细胞上Fc受体的特性与功能
Immunology. 1982 Sep;47(1):1-17.
6
IgG aggregates of different sizes stimulate or suppress Ig secretion by human lymphocytes in vitro.不同大小的IgG聚集体在体外刺激或抑制人淋巴细胞的Ig分泌。
J Clin Immunol. 1984 Mar;4(2):124-33. doi: 10.1007/BF00915046.
7
Immune complexes: biochemical and biological aspects.免疫复合物：生化与生物学方面
Indian J Pediatr. 1983 Sep-Oct;50(406):525-32. doi: 10.1007/BF02753293.
8
Pathopysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis, and pathogenic depositions.免疫复合物疾病的病理生理学方面。第二部分。吞噬作用、胞吐作用和致病性沉积。
Klin Wochenschr. 1980 Jun 16;58(12):593-605. doi: 10.1007/BF01477835.
9
Monoclonal SBF produced by a hybridoma: in-vitro and in-vivo suppression of B tumour-cell proliferation.由杂交瘤产生的单克隆SBF：对B肿瘤细胞增殖的体外和体内抑制
Immunology. 1983 Dec;50(4):595-603.
本文引用的文献
1
ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
J Exp Med. 1965 Jun 1;121(6):969-89. doi: 10.1084/jem.121.6.969.
2
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
3
Mouse thymic iso-antigens.小鼠胸腺同种抗原。
Nature. 1966 Jan 29;209(5022):521-3. doi: 10.1038/209521b0.
4
Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.19S和7S抗原受体在初次免疫反应调节中的竞争
J Exp Med. 1968 Jul 1;128(1):133-52. doi: 10.1084/jem.128.1.133.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
Inhibition of the immune response in vitro to sheep red blood cells by passive antibody.被动抗体对体外绵羊红细胞免疫反应的抑制作用。
Nature. 1969 Aug 30;223(5209):949-50. doi: 10.1038/223949a0.
7
Enhancement of antibody synthesis in vitro by mercaptoethanol.巯基乙醇对体外抗体合成的增强作用。
Cell Immunol. 1972 Jan;3(1):156-60. doi: 10.1016/0008-8749(72)90237-7.
8
Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.非抗原性与免疫耐受性：载体在诱导对半抗原的耐受性中的作用。
J Exp Med. 1971 Oct 1;134(4):1046-61. doi: 10.1084/jem.134.4.1046.
9
The mechanism of antibody-induced stimulation and inhibition of the immune response.抗体诱导的免疫反应刺激与抑制机制。
J Immunol. 1971 Apr;106(4):951-5.
Zotero 插件