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用于感染抑制和增强骨整合的双功能钛-聚多巴胺-锌涂层

Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration.

作者信息

Wang Lei, Shang Xifu, Hao Yuefeng, Wan Guoyang, Dong Lijun, Huang Degang, Yang Xin, Sun Junying, Wang Qiang, Zha Guochun, Yang Xing

机构信息

Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College Wuhu 241001 Anhui China

Department of Orthopedics, The First Affiliated Hospital, University of Science and Technology of China Hefei 230001 Anhui China.

出版信息

RSC Adv. 2019 Jan 22;9(6):2892-2905. doi: 10.1039/c8ra09112a.

DOI:10.1039/c8ra09112a
PMID:35518964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059936/
Abstract

The ideal orthopedic implant coating is expected to both inhibit microbial infection and promote osseointegration. In this study, Zn ions were immobilized on a Ti substrate a polydopamine (PDA) chemical surface modification to prepare Ti-PDA-Zn coatings. Scanning electron microscopy (SEM), atomic force microscopy (AFM), energy-dispersive X-ray spectroscope (EDS), X-ray photoelectron spectroscopy (XPS), contact analysis system, and inductively coupled plasma atomic emission spectrometry (ICP-AES) were used to analyze the morphology, composition, wettability, and zinc ions release of the coatings. The Ti-PDA-Zn coatings demonstrated excellent antibacterial activities against both and . The coatings additionally displayed good biocompatibility, as confirmed by cytoskeletal observations and cell viability assays. Furthermore, the results confirmed the excellent antibacterial properties and improved osseointegration capability of the Ti-PDA-Zn coating in the presence of . The present findings indicate that the Ti-PDA-Zn coatings prepared herein have potential application in orthopedic implantation.

摘要

理想的骨科植入物涂层既要抑制微生物感染，又要促进骨整合。在本研究中，通过聚多巴胺（PDA）化学表面改性将锌离子固定在钛基底上，以制备Ti-PDA-Zn涂层。使用扫描电子显微镜（SEM）、原子力显微镜（AFM）、能量色散X射线光谱仪（EDS）、X射线光电子能谱（XPS）、接触分析系统和电感耦合等离子体原子发射光谱仪（ICP-AES）来分析涂层的形态、成分、润湿性和锌离子释放情况。Ti-PDA-Zn涂层对[具体细菌名称1]和[具体细菌名称2]均表现出优异的抗菌活性。通过细胞骨架观察和细胞活力测定证实，该涂层还具有良好的生物相容性。此外，[具体实验或研究]结果证实了Ti-PDA-Zn涂层在[具体条件或物质存在下]具有优异的抗菌性能和改善的骨整合能力。本研究结果表明，本文制备的Ti-PDA-Zn涂层在骨科植入方面具有潜在应用价值。

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