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作为一种与食管癌及其他癌症的预后和免疫浸润相关的生物标志物：一项全面的泛癌分析。

as a Biomarker Related to Prognosis and Immune Infiltration in Esophageal Cancer and Other Cancers: A Comprehensive Pan-Cancer Analysis.

作者信息

Liu Shan-Peng, Li Xiao-Min, Liu Dan-Man, Xie Shu-Huan, Zhang Shao-Bo, Li Yu, Xie Ze-Feng

机构信息

Thoracic Surgery Department, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Breast Surgery Clinics, Guangdong Province Women and Children Hospital, Guangzhou, China.

出版信息

Front Oncol. 2022 Apr 21;12:884448. doi: 10.3389/fonc.2022.884448. eCollection 2022.

DOI:10.3389/fonc.2022.884448
PMID:35530327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069144/
Abstract

Esophageal cancer (ESCA) is a common malignant tumor with poor prognosis. Accumulating evidence indicates an important role of lysosomal-associated membrane protein 2 (LAMP2) in the progression and development of various cancers. In this study, we obtained RNA-sequencing raw count data and the corresponding clinical information for ESCA samples from The Cancer Genome Atlas and Gene Expression Omnibus databases. We comprehensively investigated the expression and prognostic significance of and relationships between expression and prognosis, different clinicopathological parameters, and immune cell infiltration in ESCA. We also obtained the differentially expressed genes between the high expression and low expression groups in ESCA and performed a functional enrichment analysis of the 250 linked genes most positively related to expression. Moreover, we performed the pan-cancer analysis of to further analyze the role of in 25 commonly occurring types of human cancer. We also verified and compared the expression of in 40 samples of human ESCA tissue and adjacent tissues. The results indicated that expression was significantly upregulated in ESCA and various human cancers. In addition, expression was associated with certain clinicopathological parameters, prognosis, and immune infiltration in ESCA and the other types of cancer. Our study represents a comprehensive pan-cancer analysis of and supports the potential use of the modulation of in the management of ESCA and various cancers.

摘要

食管癌（ESCA）是一种预后较差的常见恶性肿瘤。越来越多的证据表明，溶酶体相关膜蛋白2（LAMP2）在各种癌症的进展和发展中起重要作用。在本研究中，我们从癌症基因组图谱和基因表达综合数据库中获取了食管癌样本的RNA测序原始计数数据及相应的临床信息。我们全面研究了LAMP2在食管癌中的表达及预后意义、LAMP2表达与预后、不同临床病理参数以及免疫细胞浸润之间的关系。我们还获取了食管癌中高LAMP2表达组和低LAMP2表达组之间的差异表达基因，并对与LAMP2表达最正相关的250个关联基因进行了功能富集分析。此外，我们对LAMP2进行了泛癌分析，以进一步分析LAMP2在25种常见人类癌症类型中的作用。我们还验证并比较了40例人食管癌组织和癌旁组织中LAMP2的表达。结果表明，LAMP2表达在食管癌和各种人类癌症中显著上调。此外，LAMP2表达与食管癌及其他癌症类型的某些临床病理参数、预后和免疫浸润相关。我们的研究代表了对LAMP2的全面泛癌分析，并支持调节LAMP2在食管癌和各种癌症管理中的潜在应用。

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4
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6
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