Ni Yongsheng, Lin Wanmei, Mu Ruo-Jun, Wu Chunhua, Wang Lin, Wu Dan, Chen Su, Pang Jie
College of Food Science, Fujian Agriculture and Forestry University Fuzhou 350002 China
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University (former Nanjing University of Technology) Nanjing 210009 China
RSC Adv. 2018 Jul 24;8(47):26432-26439. doi: 10.1039/c8ra05600e.
The exploration of methods to produce a novel wound dressing with sustained drug release properties in ultrasmall scales is of great scientific and technological interest. Herein, we propose konjac glucomannan/polyvinylidene fluoride (KGM/PVDF) hybrid microfibers having hydrophilic and hydrophobic segments based on microfluidic-oriented core-sheath composite microfibers, where the KGM/PVDF hybrid microfibers are wrapped in CHOH. The morphology of KGM/PVDF microfibers is uniform, smooth, and crack-free. Enrofloxacin (Enro) is loaded onto the microfibers as a representative cargo to test their release performance. The KGM/PVDF/Enro microfibers show sustained drug release performance (13 days), excellent heat resistance, antibacterial activity and promotion of wound healing. This study is an avenue toward the microfluidic design of hydrophilic/hydrophobic hybrid microfibers as wound dressings, and it will guide the development of next-generation wound dressing.
探索在超小尺度上制备具有持续药物释放特性的新型伤口敷料的方法具有重大的科学技术意义。在此，我们基于微流控取向的核壳复合微纤维，提出了具有亲水和疏水段的魔芋葡甘聚糖/聚偏氟乙烯（KGM/PVDF）混合微纤维，其中KGM/PVDF混合微纤维包裹在CHOH中。KGM/PVDF微纤维的形态均匀、光滑且无裂纹。将恩诺沙星（Enro）作为代表性药物负载到微纤维上以测试其释放性能。KGM/PVDF/Enro微纤维表现出持续的药物释放性能（13天）、优异的耐热性、抗菌活性以及促进伤口愈合的能力。本研究为作为伤口敷料的亲水/疏水混合微纤维的微流控设计开辟了一条途径，并将指导下一代伤口敷料的开发。
