Graduate School of Health and Sports Science, Juntendo University, Inzai 270-1695, Japan.
Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Nutrients. 2022 Apr 19;14(9):1696. doi: 10.3390/nu14091696.
We previously reported that healthy adult males who consumed coix seeds for 1 week demonstrated an increased intestinal abundance of and altered peripheral lymphocyte subset percentages. However, the mechanism underlining these effects has not been elucidated. Therefore, cytokines and metabolites in plasma obtained in this study are comprehensively analyzed. A total of 56 cytokines and 52 metabolites in the plasma are quantified. Among them, 14 cytokines and 9 metabolites show significant changes in their levels following coix seed consumption. We examine the relationship between these changes and those in peripheral lymphocyte subset percentages and intestinal abundance of , which is also considerably altered following coix seed consumption. The galectin-9 concentration considerably decreased after coix seed consumption, and these changes correlate with those in cytotoxic T cells and pan T cells. Therefore, galectin-9 is possibly involved in the changes in peripheral lymphocyte subset percentages induced by coix seed consumption.
我们之前曾报道，健康成年男性连续食用薏苡仁一周后，其肠道内的丰度增加，外周血淋巴细胞亚群比例也发生了改变。然而，这些影响的作用机制尚未阐明。因此，本研究对所获得的血浆中的细胞因子和代谢物进行了全面分析。共定量了血浆中的 56 种细胞因子和 52 种代谢物。其中，14 种细胞因子和 9 种代谢物的水平在食用薏苡仁后发生了显著变化。我们研究了这些变化与外周血淋巴细胞亚群比例和肠道丰度的关系，后者在食用薏苡仁后也发生了显著改变。食用薏苡仁后，半乳糖凝集素-9的浓度显著下降，这些变化与细胞毒性 T 细胞和 pan T 细胞的变化相关。因此，半乳糖凝集素-9可能参与了薏苡仁摄入引起的外周血淋巴细胞亚群比例的变化。
