Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Apr 27;13:870054. doi: 10.3389/fendo.2022.870054. eCollection 2022.
Time-restricted feeding (TRF) has been recently reported as an effective dietary intervention for losing body weight, implying a negative energy balance, without restricting nutrient intake. However, the detailed energy balance alteration caused by TRF remains unclear. This study was a randomized controlled clinical trial using a within-subject cross-over design. Twelve healthy, normal-weighted volunteers (age: 24 ± 2.3 years; BMI: 21.9 ± 1.71 kg/m; 7 females) were studied under a rigorous control for calorie intakes, physical activities as well as sleep-wake cycle to evaluate the energy balance systematically. Each participant consumed an isocaloric diet within either a 5.5-hour TRF or 11-hour control schedule. All energy intake and excretion were traced and collected and accessed by bomb calorimetry. Energy expenditure and substrates oxidation were monitored in a metabolic chamber. TRF compared with control schedule is associated with a 22.7% increase in fecal energy loss (Δ = 32.25 ± 9.33 Kcal, p = 0.005) and a trend in increasing 14.5% urine energy loss (Δ = 6.67 ± 3.14 Kcal, p = 0.058) without change energy expenditure. In total, a negative energy balance (Δ = -45.95 ± 19.00 Kcal, p = 0.034), which was equal to -2.6% of total energy intake, has been observed during TRF interventions. In the meantime, glycemic profiles, heart rate, respiration rate as well as metabolic flexibility were also improved during TRF intervention. Taken together, our findings unravel the mystery of how TRF regulates energy balance, supporting the use of TRF as an alternative dietary strategy for weight loss.
限时进食（TRF）最近被报道为一种有效的减肥饮食干预措施，暗示着能量负平衡，而不限制营养摄入。然而，TRF 引起的详细能量平衡变化尚不清楚。本研究采用随机对照临床试验和自身交叉设计。12 名健康、体重正常的志愿者（年龄：24 ± 2.3 岁；BMI：21.9 ± 1.71 kg/m；7 名女性）在严格控制热量摄入、体力活动和睡眠-觉醒周期的情况下进行研究，以系统地评估能量平衡。每位参与者在 5.5 小时限时进食或 11 小时对照方案下摄入等热量饮食。通过弹式热量计追踪和收集所有能量摄入和排泄，并进行评估。能量消耗和底物氧化在代谢室内进行监测。与对照方案相比，TRF 与粪便能量损失增加 22.7%（Δ=32.25±9.33 Kcal，p=0.005）和尿液能量损失增加 14.5%（Δ=6.67±3.14 Kcal，p=0.058）趋势相关，而能量消耗没有变化。总的来说，TRF 干预期间观察到能量负平衡（Δ=-45.95±19.00 Kcal，p=0.034），相当于总能量摄入的-2.6%。与此同时，TRF 干预期间血糖谱、心率、呼吸率以及代谢灵活性也得到了改善。综上所述，我们的研究结果揭示了 TRF 如何调节能量平衡的奥秘，支持将 TRF 作为一种替代的减肥饮食策略。
