Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, Victoria 3168, Australia.
Chem Soc Rev. 2021 Apr 26;50(8):4872-4931. doi: 10.1039/d0cs01061h.
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention owing to their capability of achieving exquisite control over drug release via the exposure to specific stimuli. Central to the construction of such systems is the integration of cleavable linkers showing susceptibility to one stimulus or several stimuli with drugs, prodrugs or fluorogenic probes on the one hand, and nanocarriers on the other hand. This review summarises recent advances in stimulus-cleavable linkers from various research areas and the corresponding mechanisms of linker cleavage and biological applications. The feasibility of extending their applications to the majority of nanoscale drug carriers including nanomaterials, polymers and antibodies are further highlighted and discussed. This review also provides general design guidelines to incorporate stimulus-cleavable linkers into nanocarrier-based drug delivery systems, which will hopefully spark new ideas and applications.
刺激响应型纳米药物递送系统因其能够通过特定刺激实现药物释放的精确控制而受到广泛关注。这类系统的构建核心是将对一种或多种刺激敏感的可裂解连接子与药物、前药或荧光探针一方面，以及与纳米载体另一方面集成在一起。本综述总结了来自不同研究领域的刺激响应型连接子的最新进展，以及相应的连接子断裂机制和生物学应用。还进一步强调和讨论了将其应用扩展到包括纳米材料、聚合物和抗体在内的大多数纳米药物载体的可行性。本文还提供了将刺激响应型连接子纳入基于纳米载体的药物递送系统的一般设计准则，希望能激发新的思路和应用。
