Division of Applied Life Science (BK21 Four Program), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju, 660-701, Republic of Korea.
National Key Laboratory for Plant Cell Biotechnology, Agricultural Genetics Institute, km 02, Pham Van Dong Road, Co Nhue 1, Bac Tu Liem, Hanoi, 11917, Vietnam.
Planta. 2022 May 19;255(6):130. doi: 10.1007/s00425-022-03906-2.
Genome editing offers revolutionized solutions for plant breeding to sustain food production to feed the world by 2050. Therefore, genome-edited products are increasingly recognized via more relaxed legislation and community adoption. The world population and food production are disproportionally growing in a manner that would have never matched each other under the current agricultural practices. The emerging crisis is more evident with the subtle changes in climate and the running-off of natural genetic resources that could be easily used in breeding in conventional ways. Under these circumstances, affordable CRISPR-Cas-based gene-editing technologies have brought hope and charged the old plant breeding machine with the most energetic and powerful fuel to address the challenges involved in feeding the world. What makes CRISPR-Cas the most powerful gene-editing technology? What are the differences between it and the other genetic engineering/breeding techniques? Would its products be labeled as "conventional" or "GMO"? There are so many questions to be answered, or that cannot be answered within the limitations of our current understanding. Therefore, we would like to discuss and answer some of the mentioned questions regarding recent progress in technology development. We hope this review will offer another view on the role of CRISPR-Cas technology in future of plant breeding for food production and beyond.
基因组编辑为植物育种提供了革命性的解决方案，以维持到 2050 年的粮食生产，从而养活世界。因此，越来越多的人通过更宽松的立法和社区接受来认可经过基因编辑的产品。世界人口和粮食生产不成比例地增长，而按照当前的农业实践，这种增长速度永远不可能与人口增长相匹配。新兴的危机更加明显，气候变化和自然资源的流失，这些资源可以很容易地以传统方式用于培育。在这种情况下，负担得起的基于 CRISPR-Cas 的基因编辑技术带来了希望，并为旧的植物育种机器注入了最具活力和强大的燃料，以应对养活世界所涉及的挑战。是什么使 CRISPR-Cas 成为最强大的基因编辑技术？它与其他基因工程/育种技术有什么区别？它的产品会被贴上“常规”或“转基因生物”的标签吗？有太多的问题需要回答，或者在我们目前的理解范围内无法回答。因此，我们希望讨论并回答一些关于技术发展的最新进展的上述问题。我们希望这篇综述能为 CRISPR-Cas 技术在未来的植物育种、粮食生产以及其他领域的作用提供另一种视角。
