Pacheco Juliano Abreu, Molena Kelly Fernanda, Martins Camila Raíssa Oliveira Gontijo, Corona Silmara Aparecida Milori, Borsatto Maria Cristina
Postgraduate Program, EERP, University of São Paulo, Research Coordinator at the Ribeirão Preto Cancer Hospital, Sobeccan Hospital Foundation, Ribeirão Preto, Brazil.
Postgraduate Program in Pediatric Dentistry, School of Dentistry of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
Bull Natl Res Cent. 2022;46(1):140. doi: 10.1186/s42269-022-00830-z. Epub 2022 May 16.
In 2019, a viral and respiratory pathology called COVID-19 emerged in Wuhan, China, and spread to other continents. Its main symptoms include fever, cough, dyspnea, myalgia, anorexia and respiratory distress in the most severe cases, which can lead to death. Furthermore, manifestations in the oral cavity such as ageusia and dysgeusia, as well as lesions in other regions of the oral cavity, can be observed.
This systematic review and meta-analysis aimed to critically assess the clinical evidence on the use of photobiomodulation (PBMT) and antimicrobial photodynamic therapy (aPDT) for the treatment of oral lesions in patients infected with Sars-Cov-2. The literature extracted from electronic databases such as PubMed, Medline, CINAHL, and Google Scholar was screened for eligibility, and relevant articles were included. The review is limited to manuscripts published in English, Spanish and Portuguese language between December 2019 and October 2021. A total of 5 articles with 11 cases retracting PBMT and aPDT as therapeutic strategies for the regression of oral lesions and painful symptoms. The results show favoring the associated use of PBMT with aPDT ( = 0.004), and the isolated use of PBMT with the result of significant " = 0.005" and good confidence interval (7.18, 39.20) in ulcerative lesions, herpetic, aphthous, erythematous, petechiae and necrotic areas.
PBMT and aPDT could be effective in the treatment of oral lesions of patients infected with Sars-Cov-2 in a short period of time; however, more long-term randomized clinical trials studies are needed to define the therapeutic strategy.
2019年，一种名为新型冠状病毒肺炎（COVID-19）的病毒性呼吸道疾病在中国武汉出现，并蔓延至其他各大洲。其主要症状包括发热、咳嗽、呼吸困难、肌痛、厌食，在最严重的情况下会出现呼吸窘迫，甚至导致死亡。此外，还可观察到口腔表现，如味觉丧失和味觉障碍，以及口腔其他部位的病变。
本系统评价和荟萃分析旨在严格评估使用光生物调节疗法（PBMT）和抗菌光动力疗法（aPDT）治疗感染严重急性呼吸综合征冠状病毒2（Sars-Cov-2）患者口腔病变的临床证据。从PubMed、Medline、CINAHL和谷歌学术等电子数据库中提取的文献进行了资格筛选，并纳入了相关文章。该评价仅限于2019年12月至2021年10月期间以英文、西班牙文和葡萄牙文发表的手稿。共有5篇文章，11例报告了将PBMT和aPDT作为口腔病变消退和疼痛症状的治疗策略。结果显示，PBMT与aPDT联合使用效果更佳（P = 0.004），单独使用PBMT在溃疡性病变、疱疹性病变、阿弗他溃疡、红斑、瘀点和坏死区域的治疗效果显著（P = 0.005），且置信区间良好（7.18，39.20）。
PBMT和aPDT可能在短时间内有效治疗感染Sars-Cov-2患者的口腔病变；然而，需要更多长期的随机临床试验研究来确定治疗策略。
