• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名非艾滋病患者的食管念珠菌病:基层医疗诊断

Esophageal Candidiasis in a Non-HIV Patient: A Primary Care Diagnosis.

作者信息

Rodrigues Sofia, Leitão Esteves Vera, Martins Teresa G

机构信息

General Practice and Family Medicine, Unidade de Saúde Familiar (USF) Descobertas, Lisboa, PRT.

General Practice and Family Medicine, Unidade de Saúde Familiar (USF) Descobertas, Lisbon, PRT.

出版信息

Cureus. 2022 Apr 20;14(4):e24312. doi: 10.7759/cureus.24312. eCollection 2022 Apr.

DOI:10.7759/cureus.24312
PMID:35602778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9122014/
Abstract

A 74-year-old man visited his family doctor for dysphagia and was diagnosed with esophageal candidiasis. His risk factors included type 2 diabetes mellitus, long-term intake of budesonide/formoterol inhaler 160/45 µg, and pantoprazole 20 mg. He was treated with fluconazole 200 mg per day for 14 days. Other factors of immunosuppression were excluded, and his chronic medication was adapted by starting him with a proton pump inhibitor withdrawal plan and switching his inhaled device to a formoterol-only device without an inhaled corticosteroid. The patient had complete remission of the symptoms on the seventh day of treatment without relapse to date. The key point is that iatrogenic factors should be considered in the presence of esophageal candidiasis in immunocompetent patients and a therapeutic review is an important tool that should be used in every primary care appointment to refrain from long-term prescriptions without clinical indication and, consequently, to avoid adverse events.

摘要

一名74岁男性因吞咽困难就诊于家庭医生,被诊断为食管念珠菌病。他的危险因素包括2型糖尿病、长期吸入布地奈德/福莫特罗吸入剂160/45μg以及服用泮托拉唑20mg。他接受了每天200mg氟康唑治疗,疗程为14天。排除了其他免疫抑制因素,并调整了他的慢性用药,开始实施质子泵抑制剂撤药计划,并将其吸入装置换成仅含福莫特罗的装置,不含吸入性糖皮质激素。患者在治疗第7天症状完全缓解,至今未复发。关键在于,在免疫功能正常的患者出现食管念珠菌病时应考虑医源性因素,治疗评估是一项重要工具,应在每次初级保健就诊时使用,以避免无临床指征的长期处方,从而避免不良事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce98/9122014/a89c4f040a2b/cureus-0014-00000024312-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce98/9122014/a89c4f040a2b/cureus-0014-00000024312-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce98/9122014/a89c4f040a2b/cureus-0014-00000024312-i01.jpg

相似文献

1
Esophageal Candidiasis in a Non-HIV Patient: A Primary Care Diagnosis.一名非艾滋病患者的食管念珠菌病:基层医疗诊断
Cureus. 2022 Apr 20;14(4):e24312. doi: 10.7759/cureus.24312. eCollection 2022 Apr.
2
Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma.布地奈德/福莫特罗单吸入器疗法与高剂量布地奈德治疗中重度哮喘的疗效和安全性比较
Curr Med Res Opin. 2004 Sep;20(9):1403-18. doi: 10.1185/030079904X2051.
3
Combined corticosteroid and long acting beta-agonist in one inhaler for chronic obstructive pulmonary disease.用于慢性阻塞性肺疾病的吸入器中联合使用的皮质类固醇和长效β-受体激动剂。
Cochrane Database Syst Rev. 2004(3):CD003794. doi: 10.1002/14651858.CD003794.pub2.
4
Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events.福莫特罗与吸入性糖皮质激素联合常规治疗与沙美特罗与吸入性糖皮质激素联合常规治疗慢性哮喘的严重不良事件比较
Cochrane Database Syst Rev. 2010 Jan 20(1):CD007694. doi: 10.1002/14651858.CD007694.pub2.
5
Intractable hiccups caused by esophageal diverticular candidiasis in an immunocompetent adult: a case report.免疫功能正常的成年人因食管憩室念珠菌病引起的顽固性呃逆:一例报告
Int Med Case Rep J. 2017 Feb 10;10:47-50. doi: 10.2147/IMCRJ.S119787. eCollection 2017.
6
Esophageal candidiasis as a complication of inhaled corticosteroids.食管念珠菌病作为吸入性糖皮质激素的一种并发症。
Ann Allergy Asthma Immunol. 1997 Oct;79(4):333-8. doi: 10.1016/S1081-1206(10)63024-4.
7
Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.有发生严重恶化风险的哮喘患者使用布地奈德/福莫特罗维持和缓解联用吸入器的疗效和安全性:一项随机对照试验。
Lancet Respir Med. 2013 Mar;1(1):32-42. doi: 10.1016/S2213-2600(13)70007-9. Epub 2013 Mar 4.
8
Esophageal candidiasis--an adverse effect of inhaled corticosteroids therapy.食管念珠菌病——吸入性糖皮质激素治疗的一种不良反应。
J Asthma. 2009 May;46(4):399-401. doi: 10.1080/02770900902777783.
9
Case report: Proton pump inhibitor drug-related problem in pancreatic cancer patient unmasks pancreatic enzyme insufficiency.病例报告:质子泵抑制剂药物相关问题致胰腺癌患者胰腺酶不足的表现。
J Oncol Pharm Pract. 2022 Mar;28(2):457-461. doi: 10.1177/10781552211038031. Epub 2021 Sep 25.
10
[Management of the esophageal candidiasis by the primary care physician].基层医疗医生对食管念珠菌病的管理
Rev Med Suisse. 2014 May 14;10(430):1072-8.

本文引用的文献

1
Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.食管念珠菌病的诊断与治疗:最新进展。
Can J Gastroenterol Hepatol. 2019 Oct 20;2019:3585136. doi: 10.1155/2019/3585136. eCollection 2019.
2
Predictors of esophageal candidiasis among patients attending endoscopy unit in a tertiary hospital, Tanzania: a retrospective cross-sectional study.坦桑尼亚一家三级医院内镜科患者食管念珠菌病的预测因素:一项回顾性横断面研究
Afr Health Sci. 2018 Mar;18(1):66-71. doi: 10.4314/ahs.v18i1.10.
3
Possible Risk Factors for Candida Esophagitis in Immunocompetent Individuals.
免疫功能正常个体患念珠菌性食管炎的可能危险因素。
Gastroenterology Res. 2018 Jun;11(3):195-199. doi: 10.14740/gr1019w. Epub 2018 May 31.
4
Course of Esophageal Candidiasis and Outcomes of Patients at a Single Center.食管念珠菌病的病程及单中心患者的结局。
Clin Gastroenterol Hepatol. 2019 Jan;17(1):200-202.e1. doi: 10.1016/j.cgh.2018.04.035. Epub 2018 Apr 24.
5
Candida Esophagitis.念珠菌性食管炎
N Engl J Med. 2017 Apr 20;376(16):1574. doi: 10.1056/NEJMicm1614893.
6
Long-Term Trends in Esophageal Candidiasis Prevalence and Associated Risk Factors with or without HIV Infection: Lessons from an Endoscopic Study of 80,219 Patients.食管念珠菌病患病率的长期趋势及有无HIV感染的相关危险因素:来自一项对80219例患者的内镜研究的经验教训
PLoS One. 2015 Jul 24;10(7):e0133589. doi: 10.1371/journal.pone.0133589. eCollection 2015.
7
Proton pump inhibitor therapy and potential long-term harm.质子泵抑制剂治疗及潜在的长期危害。
Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):3-8. doi: 10.1097/MED.0000000000000031.
8
Inhaled corticosteroids for stable chronic obstructive pulmonary disease.吸入性糖皮质激素用于稳定期慢性阻塞性肺疾病
Cochrane Database Syst Rev. 2012 Jul 11;2012(7):CD002991. doi: 10.1002/14651858.CD002991.pub3.
9
Esophageal candidiasis--an adverse effect of inhaled corticosteroids therapy.食管念珠菌病——吸入性糖皮质激素治疗的一种不良反应。
J Asthma. 2009 May;46(4):399-401. doi: 10.1080/02770900902777783.
10
A case of type 2 diabetes mellitus in an elderly patient with rapid attenuation of insulin secretion that resembled fulminant type 1 DM but with incomplete beta cell damage.一名老年2型糖尿病患者,胰岛素分泌迅速衰减,类似于暴发性1型糖尿病,但β细胞损伤不完全。
Endocr J. 2006 Oct;53(5):633-7. doi: 10.1507/endocrj.k06-008. Epub 2006 Aug 8.