Rodrigues Sofia, Leitão Esteves Vera, Martins Teresa G
General Practice and Family Medicine, Unidade de Saúde Familiar (USF) Descobertas, Lisboa, PRT.
General Practice and Family Medicine, Unidade de Saúde Familiar (USF) Descobertas, Lisbon, PRT.
Cureus. 2022 Apr 20;14(4):e24312. doi: 10.7759/cureus.24312. eCollection 2022 Apr.
A 74-year-old man visited his family doctor for dysphagia and was diagnosed with esophageal candidiasis. His risk factors included type 2 diabetes mellitus, long-term intake of budesonide/formoterol inhaler 160/45 µg, and pantoprazole 20 mg. He was treated with fluconazole 200 mg per day for 14 days. Other factors of immunosuppression were excluded, and his chronic medication was adapted by starting him with a proton pump inhibitor withdrawal plan and switching his inhaled device to a formoterol-only device without an inhaled corticosteroid. The patient had complete remission of the symptoms on the seventh day of treatment without relapse to date. The key point is that iatrogenic factors should be considered in the presence of esophageal candidiasis in immunocompetent patients and a therapeutic review is an important tool that should be used in every primary care appointment to refrain from long-term prescriptions without clinical indication and, consequently, to avoid adverse events.
一名74岁男性因吞咽困难就诊于家庭医生,被诊断为食管念珠菌病。他的危险因素包括2型糖尿病、长期吸入布地奈德/福莫特罗吸入剂160/45μg以及服用泮托拉唑20mg。他接受了每天200mg氟康唑治疗,疗程为14天。排除了其他免疫抑制因素,并调整了他的慢性用药,开始实施质子泵抑制剂撤药计划,并将其吸入装置换成仅含福莫特罗的装置,不含吸入性糖皮质激素。患者在治疗第7天症状完全缓解,至今未复发。关键在于,在免疫功能正常的患者出现食管念珠菌病时应考虑医源性因素,治疗评估是一项重要工具,应在每次初级保健就诊时使用,以避免无临床指征的长期处方,从而避免不良事件。