Liu Ren, Lee Jihwan, Tchoe Youngbin, Pre Deborah, Bourhis Andrew M, D'Antonio-Chronowska Agnieszka, Robin Gaelle, Lee Sang Heon, Ro Yun Goo, Vatsyayan Ritwik, Tonsfeldt Karen J, Hossain Lorraine A, Phipps M Lisa, Yoo Jinkyoung, Nogan John, Martinez Jennifer S, Frazer Kelly A, Bang Anne G, Dayeh Shadi A
Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Adv Funct Mater. 2022 Feb 16;32(8). doi: 10.1002/adfm.202108378. Epub 2021 Nov 6.
We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.
我们报告了创新的可扩展、垂直、超尖锐纳米线阵列，这些阵列可单独寻址，以实现细胞内电位的长期原生记录。从神经元和心肌细胞的三维组织样网络中获得了稳定的细胞内电位振幅。对于高保真细胞内电生理记录而言，个体电可寻址性是必要的。本研究为预测性、高通量和低成本的电生理药物筛选平台铺平了道路。
