Orthopedic Rehabilitation Unit and Research Lab in Biomechanics, Rehabilitation and Ergonomics, Ospedale San Giuseppe, Istituto Auxologico Italiano, IRCCS, Via Cadorna 90, 28824, Verbania, Italy.
Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey.
J Therm Biol. 2022 May;106:103250. doi: 10.1016/j.jtherbio.2022.103250. Epub 2022 May 4.
Currently available treatments for the management of obesity struggle to provide clinically significant weight loss and reduction of the chronic low-grade inflammatory state in order to reduce obesity-related complications. This scoping review aims to provide an up-to-date picture of the therapeutic effects of Whole-Body Cryostimulation (WBC) in patients with obesity and evidence-based indications for its complementary use in the treatment of obesity. We searched the literature until the end of August 2021, retrieving 8 eligible studies out of 856, all evaluated for their methodological quality using the Downs and Black checklist. Overall, the limited data presented in this review article seem to support the efficacy of WBC as an adjuvant treatment in obesity. The cryogenic stimulus has important anti-inflammatory/antioxidant effects and its effectiveness is directly related to the individual percentage of fat mass and initial fitness capacity, mimicking an exercise-induced effect. Based on the limited results gathered, WBC emerges as a promising adjuvant therapy to reduce systemic inflammation, oxidative stress, abdominal obesity, and body mass. However, the data presented in this review article fail to reach definitive conclusions with regards to the efficacy of WBC in the treatment of obesity. Application of WBC protocols yields the potential to widen the therapeutic armor for the treatment of obesity and obesity-related disorders but larger, high-quality studies are still needed.
目前用于肥胖管理的治疗方法难以提供临床上显著的体重减轻和慢性低度炎症状态的减轻，以减少肥胖相关并发症。本范围综述旨在提供全身体冷冻刺激（WBC）治疗肥胖患者的治疗效果的最新情况，并提供其在肥胖治疗中补充使用的循证指征。我们搜索了文献，直到 2021 年 8 月底，从 856 篇中检索到 8 篇符合条件的研究，均使用唐斯和布莱克清单评估其方法学质量。总体而言，本综述文章中呈现的有限数据似乎支持 WBC 作为肥胖辅助治疗的疗效。冷冻刺激具有重要的抗炎/抗氧化作用，其有效性直接与个体脂肪质量百分比和初始健身能力相关，模拟运动引起的效果。基于收集到的有限结果，WBC 作为一种有前途的辅助治疗方法，可以减轻全身炎症、氧化应激、腹型肥胖和体重。然而，本文呈现的数据未能就 WBC 在肥胖治疗中的疗效得出明确结论。应用 WBC 方案有可能扩大肥胖和肥胖相关疾病的治疗武器库，但仍需要更大规模、高质量的研究。
