Sahoo Swapnajeet, Suman Arzoo, Mehra Aseem, Nehra Ritu, Bhalla Ashish, Puri Goverdhan Dutt, Grover Sandeep
Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Neurosci Rural Pract. 2022 Mar 9;13(2):236-245. doi: 10.1055/s-0042-1743445. eCollection 2022 Apr.
The literature on presence of cognitive deficits in patients recovered from coronavirus disease 2019 (COVID-19) infection is emerging. However, the data on whether cognitive deficits have its onset during the acute phase of illness has not been evaluated extensively. This article estimates the level of cognitive functioning of patients with COVID-19 while they were admitted to COVID-designated wards. Secondary objectives were to assess the influence of medical comorbidities, severity of COVID-19 infection, and depressive and anxiety symptoms on cognitive functioning in patients with COVID-19 infection. Sixty-six clinically stable patients with COVID-19 infection were evaluated during their inpatient stay on Hindi Montreal Cognitive Assessment scale (H-MoCA), Hindi Mini-Mental State Examination (HMSE) scale, Patient Health Questionnaire-9, and Generalized Anxiety Disorder Questionnaire -7. The mean age of the study participants was 39.85 (standard deviation [SD] 16.89) years and the participants were evaluated after 9.34 (SD 4.98; median 9.0) days of being diagnosed with COVID-19 infection. About one-fourth (28.8%; = 19) of the participants had cognitive impairment on HMSE and about two-fifths ( = 26; 39.39%) had cognitive impairment as per the cutoff used for H-MoCA. A higher level of cognitive deficits were seen among participants who were older, diagnosed with diabetes mellitus, and those who required oxygen support during their hospital stay prior to assessment. Low cognitive score was found in one-fourth (28.8%) to two-fifths (39.9%) of the persons, depending on the assessment scale among those with acute COVID-19 infection. Low cognitive score was more prevalent among the elderly, those with diabetes mellitus, and those who required oxygen support prior to the assessment.
关于2019冠状病毒病（COVID-19）感染康复患者存在认知缺陷的文献正在不断涌现。然而，关于认知缺陷是否在疾病急性期开始的数据尚未得到广泛评估。 本文评估了COVID-19患者入住COVID指定病房时的认知功能水平。次要目标是评估合并症、COVID-19感染严重程度以及抑郁和焦虑症状对COVID-19感染患者认知功能的影响。 对66例临床稳定的COVID-19感染患者在住院期间进行了印地语蒙特利尔认知评估量表（H-MoCA）、印地语简易精神状态检查表（HMSE）、患者健康问卷-9和广泛性焦虑障碍问卷-7评估。 研究参与者的平均年龄为39.85岁（标准差[SD]16.89），在被诊断为COVID-19感染9.34天（SD 4.98；中位数9.0）后进行评估。约四分之一（28.8%；n = 19）的参与者在HMSE上存在认知障碍，约五分之二（n = 26；39.39%）根据H-MoCA使用的临界值存在认知障碍。在年龄较大、被诊断患有糖尿病以及在评估前住院期间需要吸氧支持的参与者中，观察到更高水平的认知缺陷。 根据急性COVID-19感染患者的评估量表，四分之一（28.8%）至五分之二（39.9%）的人认知得分较低。认知得分较低在老年人、患有糖尿病的人以及在评估前需要吸氧支持的人中更为普遍。
