Xu Yao, Abdelazeem Basel, Abbas Kirellos Said, Lin Yile, Wu Haixiao, Zhou Fei, Peltzer Karl, Chekhonin Vladimir P, Li Shu, Li Huiyang, Ma Wenjuan, Zhang Chao
Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
The Sino-Russian Joint Research Center for Bone Metastasis in Malignant Tumor, Tianjin, China.
Front Med (Lausanne). 2022 Jun 2;9:899544. doi: 10.3389/fmed.2022.899544. eCollection 2022.
To investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database.
The retrospective cohort study included malignant cancer patients with synchronous BM diagnosed from 2010 to 2018 in the SEER database. The frequencies and proportion of non-cancer COD were calculated and analyzed in different genders, ages, and races subgroups.
A total of 97,997 patients were deceased and included into the current study and 6,782 patients were died of non-cancer causes with a male predominance ( = 4,515, 66.6%). Around half of deaths ( = 3,254, 48.0%) occurred within 6 months after diagnosis while 721 patients were deceased after 3 years. Lung and bronchus cancer, prostate cancer, breast cancer, kidney and renal pelvis cancer, and liver cancer were proved to be the top five cancer types resulting in non-cancer caused death. Cardiovascular and cerebrovascular diseases were the leading non-cancer cause of death ( = 2,618), followed by COPD and associated conditions ( = 553) and septicemia, infectious and parasitic diseases ( = 544). Sub-analyses stratified by gender, age and race were performed and the similar results with slightly difference were observed.
Cardiovascular and cerebrovascular diseases were the main non-cancer cause of death in cancer patients with synchronous BM. Other non-cancer causes included COPD, septicemia, infectious and parasitic diseases, and so on. These findings should be considered by physicians. Physicians can counsel cancer patients with BM regarding survivorship with death causes screening and focus on prevention of non-cancer deaths.
基于监测、流行病学和最终结果（SEER）数据库，调查同步骨转移（BM）癌症患者的非癌症死亡原因（COD）。
这项回顾性队列研究纳入了2010年至2018年在SEER数据库中诊断为同步BM的恶性癌症患者。计算并分析了不同性别、年龄和种族亚组中非癌症COD的频率和比例。
共有97,997例患者死亡并纳入本研究，6,782例患者死于非癌症原因，男性居多（=4,515，66.6%）。约一半的死亡（=3,254，48.0%）发生在诊断后6个月内，721例患者在3年后死亡。肺癌和支气管癌、前列腺癌、乳腺癌、肾癌和肾盂癌以及肝癌被证明是导致非癌症死亡的前五种癌症类型。心血管和脑血管疾病是主要的非癌症死亡原因（=2,618），其次是慢性阻塞性肺疾病（COPD）及其相关病症（=553）和败血症、感染性和寄生虫病（=544）。进行了按性别、年龄和种族分层的亚分析，观察到结果相似但略有差异。
心血管和脑血管疾病是同步BM癌症患者主要的非癌症死亡原因。其他非癌症原因包括COPD、败血症、感染性和寄生虫病等。医生应考虑这些发现。医生可以就死亡原因筛查向患有BM的癌症患者提供关于生存的咨询，并关注非癌症死亡的预防。
