COVID-19 检测策略的进展。
Advancements in Testing Strategies for COVID-19.
机构信息
Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China.
Department of Wildlife and Ecology, Faculty of Fisheries and Wildlife, University of Veterinary and Animal Sciences-UVAS, Lahore 54000, Pakistan.
出版信息
Biosensors (Basel). 2022 Jun 13;12(6):410. doi: 10.3390/bios12060410.
The SARS-CoV-2 coronavirus, also known as the disease-causing agent for COVID-19, is a virulent pathogen that may infect people and certain animals. The global spread of COVID-19 and its emerging variation necessitates the development of rapid, reliable, simple, and low-cost diagnostic tools. Many methodologies and devices have been developed for the highly sensitive, selective, cost-effective, and rapid diagnosis of COVID-19. This review organizes the diagnosis platforms into four groups: imaging, molecular-based detection, serological testing, and biosensors. Each platform's principle, advancement, utilization, and challenges for monitoring SARS-CoV-2 are discussed in detail. In addition, an overview of the impact of variants on detection, commercially available kits, and readout signal analysis has been presented. This review will expand our understanding of developing advanced diagnostic approaches to evolve into susceptible, precise, and reproducible technologies to combat any future outbreak.
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2），也称为导致 COVID-19 的病原体，是一种可能感染人类和某些动物的烈性病原体。COVID-19 的全球传播及其新兴变异需要开发快速、可靠、简单且低成本的诊断工具。已经开发出许多方法和设备来高度敏感、选择性、具有成本效益且快速诊断 COVID-19。本综述将诊断平台分为四组：成像、基于分子的检测、血清学检测和生物传感器。详细讨论了每个平台的原理、进展、用途以及监测 SARS-CoV-2 的挑战。此外，还介绍了变异对检测的影响、市售试剂盒和读出信号分析的概述。本综述将扩展我们对开发先进诊断方法的理解，使其演变为敏感、精确和可重复的技术，以应对任何未来的爆发。
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